Interleukin-17inhibition With Secukinumab Improves Sudomotor Dysfunction in Psoriatic Arthritis

Abstract

Psoriatic arthritis (PsA) is a relapsing inflammatory disease, most commonly a seronegative oligoarthritis found in patients with psoriasis, characterized by the absence of rheumatoid factor in serum, with differentiating features of distal joint involvement and in extreme cases of arthritis mutilans (which is a destructive form of PsA). Cardiovascular autonomic and peripheral sympathetic neuropathy occurs in PsA. However, there is no specific treatment recommendation for autonomic neuropathy (AN) in psoriatic diseases. Secukinumab, a recently approved therapeutic advancement for psoriasis and psoriatic arthritis, is an immunoglobulin G (IgG) 1k fully monoclonal antibody that selectively inhibits the effector function of interleukin (IL)-17A. Its effect on sudomotor dysfunction in PsA has not yet been reported. This is the first reported observation of improvement in peripheral sympathetic autonomic neuropathy with secukinumab in PsA. We report a case of a 52-year-old male with PsA on methotrexate 15 mg/week with severe disease activity treated with the addition of subcutaneous secukinumab 150 mg once a week for 5 w followed by once a month dose. We found significant improvement in sudomotor dysfunction after 4 and 8 w of treatment.

Molecular Dynamics Simulations of the Stk630921 Interactions to Interleukin-17a

“…All members of the IL-17 family are potent pro-inflammatory cytokines that are primarily secreted by Th17 cells and are also produced by other cells, including NK cells, macrophages, neutrophils, dendritic cells, and mast cells [1]. The pathogenicity of IL-17 has been found in several diseases, including psoriasis [2], rheumatoid arthritis [3], psoriatic arthritis [4], cancer [5], diabetes [6] and end-stage renal disease [7]. Serum levels of several Th17associated cytokines, including IL-17A and IL-21, were found to be higher in diabetic patients compared to controls [8].…”

Association of Anti-Cyclic Citrullinated Peptide Antibody in a Sample of Adult Patients With Psoriasis and Psoriatic Arthropathy

“…Metabolic syndrome-induced oxidative stress may play an important role in the development of cognitive impairment, neuropathy, and depressive disorders while its effect on cell proliferation, angiogenesis, and apoptosis may contribute to the pathogenesis of colorectal cancer [3]. In addition, autonomic dysfunction may be occur with varying frequency and intensity, sympathetic nervous system dysfunction can lead to severe consequences including myocardial infarction, arrhythmias, and sudden cardiac death [4].…”