Interleukin-18 gene promoter polymorphisms and the risk of esophageal squamous cell carcinoma

Abstract

This study shows for the first time an association between IL-18 gene promoter -137 G/C polymorphism may contribute represent a genetic risk factor for ESCC in a Chinese population.

Interleukin-18 promoter polymorphism is associated with lung cancer: A case-control study

“…Similarly, Khalili-Azad et al found no such association with breast cancer in a population of the same ethnic background [17], despite a positive association with IL-18 promoter polymorphism. In contrast, Wei et al [11] and Liu et al [12] found an association between IL-18 promoter haplotype and esophageal squamous cell carcinoma and prostate cancer in Chinese populations. These conflicting data may be due to differences in the linkage disequilibrium in different ethnic backgrounds.…”

“…Although the functional consequence of -656 polymorphism is not clear, -607 and -137 SNPs can cause differences in transcription factor binding, and may have an impact on IL-18 expression [10]. IL-18 promoter polymorphisms (-607 or -137) were previously shown to be statistically associated with esophageal squamous cell carcinoma [11] and prostate cancer [12] in Chinese populations, colorectal cancer in a Greek population [13], ovarian cancer in native Hawaiians [14], and breast cancer in Iranians [17]. In contrast, there was no significant association between IL-18 polymorphism and squamous cell carcinoma of the head and neck in Iran [16], or with squamous oral carcinoma in Greece [15].…”

Immunotherapeutic Approach for Better Management of Cancer - Role of IL-18

“…Haplotype analysis showed statistical significance in patients with stomach cancer -607 C/-137 C and -607 A/-137 G and in patients with colorectal cancer and esophageal squamous cell carcinoma (Wei et al, 2007;Haghshenas et al, 2009). …”

Association between the -607 C > A polymorphism in interleukin-18 gene promoter with gastrointestinal cancer risk: a meta-analysis

“…Variations in the IL-18 gene promoter are able to influence IL-18 production and activity. While results are still inconclusive, several emerging studies have reported the associations between -607 C/A polymorphism in the IL-18 gene and gastrointestinal cancer risk (Nikiteas et al, 2007;Wei et al, 2007;Haghshenas et al, 2009;Babar et al, 2012). This controversy may due to several factors, including differences between cancer sites, ethnicity, sample sizes, study designs and assay characteristics.…”

“…Based on our preliminary search criteria, 712 were excluded as they did not satisfy the inclusion criteria. Finally, five case-control studies from four publications with 1618 cases and 1155 controls were included in the meta-analysis (Nikiteas et al, 2007;Wei et al, 2007;Haghshenas et al, 2009;Babar et al, 2012). All the included journal articles were published between 2007 and 2012.Three of these studies were conducted in Asian populations, and two in Caucasian populations.…”