Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population

Messaoudi, Safia; Dandana, Maryam T.; Magdoud, Kalthoum; Meddeb, S.; Slama, Neila Ben; Hizem, Sondes; Mahjoub, Touhami

doi:10.1016/j.jri.2011.12.002

Cited by 16 publications

(17 citation statements)

References 28 publications

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“…This polymorphism was not associated with RPL under either model (dominant: P = 0.31, OR = 0.82, 95% CI [0.56,1.21] S5A Fig; recessive: P = 0.17, OR = 0.73, 95% CI [0.47,1.14] S5B Fig). Two articles with 517 patients with RPL and 524 controls investigating the IL-18 (-119A/C) polymorphism were included[9, 40]. The effects analysis revealed no association between the IL-18 (-119A/C) polymorphism and RPL with either model (dominant: P = 0.50, OR = 0.92, 95% CI [0.72,1.17] S5C Fig; recessive: P = 0.69, 95% CI 1.09[0.71,1.68] S5D Fig).…”

Section: Resultsmentioning

confidence: 99%

“…The heterogeneity among these studies was not significant. Three studies investigated the IL-18 (-656C/A) and IL-18 (-105G/A) polymorphisms with 1001 patients with RPL and 992 controls and were included in the analysis[9, 40, 41]. The P-values and 95% CIs demonstrated that the IL-18 (-656C/A) polymorphism is not associated with RPL (dominant: P = 0.09, OR = 1.74, 95% CI [0.92,3.28] S5E Fig; recessive: P = 0.12, OR = 1.66, 95% CI [0.88,3.16] S5F Fig), but IL-18 (-105G/A) shows a positive association (dominant: P = <0.01, OR = 1.41, 95% CI [1.17,1.70] Fig 6A; recessive: P<0.01, OR = 2.56, 95% CI [1.26,5.19] Fig 6B).…”

Section: Resultsmentioning

confidence: 99%

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Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Zhang

Bao

et al. 2017

PLoS ONE

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Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0.62,0.96]), IL-6 (-634C/G) (P<0.001, 95% CI 2.91[2.01,4.22]), IL-10 (-1082G/A, –819T/C) (P = 0.01, 95% CI 0.80[0.67,0.96]; P<0.01, 95% CI 0.66[0.49,0.89]), and IL-18 (-137G/C, -105G/A) (P<0.01, 95% CI 1.69[1.24,2.31]; P = <0.01, 95% CI 1.41[1.17,1.70]) consistently associated with RPL after meta-analysis. IL-17A rs2275913 and IL-17F rs763780, IL-21 rs2055979 and rs13143866, IL-1β (-31C/T), IL-6 (-2954G/C), and IL-10 (-536A/G) were reported only once as having a significant association with RPL. The potential mechanism underlying miscarriage and these polymorphisms and future research directions are also discussed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Zhang

Bao

et al. 2017

PLoS ONE

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“…Based on full text reading, one review article and two articles referring to IL‐18 serum levels were excluded. Five articles published between 2006 and 2015 reporting the association of IL‐18 ‐137 G / C mutation on RPL risk and genotype distributions in the control group were determined to be not deviated from HWE and were included in the meta‐analysis . Three articles reported the association between IL‐18 ‐607 C / A polymorphism and the risk of RPL; two of these articles detailed genotype distributions among the controls that departed from the HWE .…”

Section: Resultsmentioning

confidence: 99%

“…Five articles involving 1208 RPL cases and 1233 controls were included in the meta‐analysis . There was no significant heterogeneity between the studies under any genetic models.…”

Section: Resultsmentioning

confidence: 99%

Interleukin‐18 gene polymorphisms and risk of recurrent pregnancy loss: A systematic review and meta‐analysis

Chen

Yang

et al. 2015

J of Obstet and Gynaecol

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Interleukin-18 (IL-18) plays a potential pathological role in recurrent pregnancy loss (RPL). The results of published studies on the relationship between IL-18 gene promoter polymorphisms (-137G/C and-607C/A) and RPL risk remain controversial. This meta-analysis was performed to evaluate the association of IL-18, -137G/C and-607C/A gene polymorphisms with the risk of RPL under recessive, dominant and additive genetic models. A literature search was conducted in Medline, Embase and Web of Science for studies that described the effect of IL-18 gene polymorphisms on RPL risk. The numbers of each -137G/C and-607C/A genotype in the case and control groups were extracted. Quality of the original studies' methodology was also assessed. Meta-analysis was performed using Stata 13.1 software and the fixed effect model was used. Five articles were included in this meta-analysis. No significant heterogeneity between the studies was noted. The IL-18 -137 G/C polymorphism was significantly associated with an increased risk of RPL under a recessive genetic model (CC vs. GG + CG: odds ratio = 1.56, 95% confidence interval = 1.13 ~ 2.15). For the -607C/A mutation, we failed to find any association under any genetic models. The Egger's regression asymmetry test showed no publication bias. Our present study indicates a positive association between the CC genotype of the IL-18 -137G/C gene and RPL risk. Future well-designed large studies are needed to validate the association between IL-18 gene polymorphisms and the risk of RPL.

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“…[117] A more recent study extended to a Tunisian population the analysis of the same haplotype of four SNPs of Il-18 [−656C/A (rs1946519), −137G/C (rs187238), −119A/C (rs360718), and −105G/A (rs360717)]. [118] A-G-A-A and C-G-A-A were associated with an increased risk of RPL (OR: 20.73 and 5.23, respectively), and C-G-A-G conferred a protection (OR: 0.29). Overall, these allelic combinations are found in 54% of the controls and 35% of the patients, which give them an important potential predictive value.…”

Section: Cytokines and Immune Cells Dialogmentioning

confidence: 99%

Genetic regulation of recurrent spontaneous abortion in humans

Vaiman¹

2015

Biomed J

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Recurrent pregnancy loss, defined as a pregnancy failure occurring before 24 weeks of gestation more than two or three times according to most definitions, is a fertility defect encountered in 1-5% of the patients. This defect is of course of multifactorial origin. Among the possible origins of recurrent pregnancy loss are uterine structural defaults, defective ploidy control of the embryo, defective immunological dialog between the embryo (or the fetus) and the uterus sometimes in relation with immunological disorders (such as autoimmune diseases), thrombophilia, and free radical metabolism imbalance. Numerous studies attempted to correlate variants of genes supposed to be intervening in the different facets of the early maternal-fetal or maternal-embryonic dialog, and eventually modify the outcome of fertilization, leading to success or failure of post-implantation development. The objective of the present review is to portray the major genes and gene polymorphisms studied for their putative association with recurrent pregnancy loss. Most of these genes have been studied as candidate genes for which strong biological arguments were put forward as to their putative involvement in recurrent pregnancy loss. They were mostly studied by genetic analysis, often in various populations of different ethnic origins, throughout the world. Some of these studies were available only in English as abstracts and were nevertheless used if the information was given with enough detail. With the space being too short to depict all the available literature, different major pathways releva nt to the scientific question are presented without any attempt to hide the fact that discordant views often aroused for a given gene. rather attempt to categorize the factors that were analyzed according to their biological functions and summarize their putative effects.

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Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population

Cited by 16 publications

References 28 publications

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Interleukin‐18 gene polymorphisms and risk of recurrent pregnancy loss: A systematic review and meta‐analysis

Genetic regulation of recurrent spontaneous abortion in humans

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