Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers

Mierzchała-Pasierb, Magdalena; Krzystek−Korpacka, Małgorzata; Leśnik, Patrycja; Adamik, Barbara; Płaczkowska, Sylwia; Serek, Paweł; Gamian, Andrzej; Lipińska-Gediga, Małgorzata

doi:10.1016/j.cyto.2019.04.003

Cited by 21 publications

(25 citation statements)

References 29 publications

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“…Similarly, Mierzchala-Pasierb M et al. ( 43 ) conducted an observational and prospective study and reported that there were no significant differences for the CRP levels between any subgroups according to disease seriousness. The possible explanation is that the CRP peaks only at 24–48 h after the onset of infections or tissue damage ( 33 , 44 ), which determines the poor timeliness of CRP.…”

Section: Discussionmentioning

confidence: 97%

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis

et al. 2021

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BackgroundThe current study aimed to evaluate the relationship between the neutrophil-to-lymphocyte ratio (NLR) combined with interleukin (IL)-6 on admission day and the 28-day mortality of septic patients.Material and MethodsWe conducted an observational retrospective study. Patients with presumed sepsis were included. We observed the correlation of studied biomarkers (NLR, IL-6, PCT, and CRP) and the severity scores (APACHE II and SOFA scores) by plotting scatter plots. The relationships of the studied biomarkers and 28-day mortality were evaluated by using Cox regression model, receiver-operating characteristic (ROC) curve, and reclassification analysis.ResultsA total of 264 patients diagnosed with sepsis were enrolled. It was revealed that IL-6 had the strongest correlation with both APACHE II and SOFA scores, followed by the NLR and PCT, and there was no obvious correlation between CRP and the illness severity. NLR and IL-6 were independent predictors of the 28-day mortality in septic patients in the Cox regression model [NLR, odds ratio 1.281 (95% CI 1.159–1.414), P < 0.001; IL-6, odds ratio 1.017 (95% CI 1.005–1.028), P=0.004]. The area under the ROC curve (AUC) of NLR, IL-6 and NLR plus IL-6 (NLR_IL-6) was 0.776, 0.849, and 0.904, respectively.ConclusionOur study showed that the levels of NLR and IL-6 were significantly higher in the deceased patients with sepsis. NLR and IL-6 appeared to be independent predictors of 28-day mortality in septic patients. Moreover, NLR combined with IL-6 could dramatically enhance the prediction value of 28-day mortality.

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Section: Discussionmentioning

confidence: 97%

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis

et al. 2021

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“…Pyroptosis of neutrophils and monocytes is a major source of IL-18 during infection [ 13 ]. An increased serum IL-18 level indicates the severity of sepsis and is correlated with worse prognosis [ 14 , 15 ]. A high concentration of serum IL-1 β also has an adverse effect on the prognosis of septic shock [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis

Guo

Wang

Cui

2021

Mediators of Inflammation

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Sepsis is defined as a life-threatening disease involving multiple organ dysfunction caused by dysregulated host responses to infection. To date, sepsis remains a dominant cause of death among critically ill patients. Pyroptosis is a unique form of programmed cell death mediated by the gasdermin family of proteins and causes lytic cell death and release of proinflammatory cytokines. Although there might be some positive aspects to pyroptosis, it is regarded as harmful during sepsis and needs to be restricted. Autophagy was originally characterized as a homeostasis-maintaining mechanism in living cells. In the past decade, its function in negatively modulating pyroptosis and inflammation during sepsis has attracted increased attention. Here, we present a comprehensive review of the regulatory effect of autophagy on pyroptosis during sepsis, including the latest advances in our understanding of the mechanism and signaling pathways involved, as well as the potential therapeutic application in sepsis.

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“…In healthy subjects, IL-18 levels range between 100 and 200 pg/ ml (Lauw et al, 1999;Taniguchi et al, 1997) and increase during infection reaching values around 1,000 pg/ml with a parallel increase in IFN-γ concentrations (median value of 25 pg/ml vs. undetectable levels in healthy controls; Lauw et al, 1999). In patients with septic shock, IL-18 serum concentrations are 6-15 times higher compared with controls (Esquerdo et al, 2017;Mierzchala-Pasierb et al, 2019).…”

Section: Il-18 and Infectionsmentioning

confidence: 99%

“…In healthy subjects, IL‐18 levels range between 100 and 200 pg/ml (Lauw et al, 1999; Taniguchi et al, 1997) and increase during infection reaching values around 1,000 pg/ml with a parallel increase in IFN‐γ concentrations (median value of 25 pg/ml vs. undetectable levels in healthy controls; Lauw et al, 1999). In patients with septic shock, IL‐18 serum concentrations are 6–15 times higher compared with controls (Esquerdo et al, 2017; Mierzchala‐Pasierb et al, 2019). Although IL‐18 seems to be involved in resistance to different pathogens, elevated levels may also be detrimental by inducing hyperinflammation‐related injury, such as sepsis‐induced cardiac dysfunction (Okuhara et al, 2017).…”

Section: Il‐18 and Infectionsmentioning

confidence: 99%

IL‐18 and infections: Is there a role for targeted therapies?

Vecchiè

Bonaventura

Toldo

et al. 2020

Journal Cellular Physiology

104

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Interleukin (IL)-18 is a pro-inflammatory cytokine belonging to the IL-1 family, first identified for its interferon-γ-inducing properties. IL-18 regulates both T helper (Th) 1 and Th2 responses. It acts synergistically with IL-12 in the Th1 paradigm, whereas with IL-2 and without IL-12 it can induce Th2 cytokine production from cluster of differentation (CD)4 + T cells, natural killer (NK cells, NKT cells, as well as from Th1 cells. IL-18 also plays a role in the hemophagocytic lymphohistiocytosis, a lifethreatening condition characterized by a cytokine storm that can be secondary to infections. IL-18-mediated inflammation was largely studied in animal models of bacterial, viral, parasitic, and fungal infections. These studies highlight the con-1640 | VECCHIÉ ET AL.

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Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers

Cited by 21 publications

References 29 publications

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis

Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis

IL‐18 and infections: Is there a role for targeted therapies?

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