Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population

Yang, Jie; Hu, Zhibin; Xu, Yaochu; Jin, Sanli; Niu, Juyin; Hu, Xu; Guo, Jiantao; Wei, Qingyi; Wang, Xinru; Shen, Hongbing

doi:10.1016/j.canlet.2004.07.012

Cited by 77 publications

(74 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar experimental findings were made in the study of Chinese population, when the same genotype was associated with gastric atrophy and hypochlorhydria (Yang et al, 2004).…”

Section: Discussionsupporting

confidence: 85%

“…For example, a haplotype that combines both homozygous risk alleles occurs two times more often in the African-Americans than in the Europeans (Zabaleta et al, 2008). In another study, Jie Yang and colleagues conducted haplotype analysis that defined the IL1B-31T and -511C as risk alleles, while a synergistic effect between the two loci was not found (Yang et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Similar experimental findings were made in the study of Chinese population, when the same genotype was associated with gastric atrophy and hypochlorhydria (Yang et al, 2004).…”

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Of the remaining 38 publications, three were eliminated, due to reporting duplicate data 17, 18, 19. Ultimately, 37 studies from 35 publications 6, 10, 14, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 including 6108 cases and 8980 controls were included in the meta‐analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Hua-yong

Zong³

et al. 2016

J Cellular Molecular Medi

View full text Add to dashboard Cite

Gastric cancer is one of the most common malignancies worldwide. Interleukin‐1‐beta (IL‐1β) is a pro‐inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between IL‐1B 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta‐analysis to reassess the association. A systematic literature search of the PubMed and EMBASE databases identified 37 studies with 6108 cases and 8980 controls for this meta‐analysis. The crude odd ratios (ORs) and the 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Meta‐regression was used to determine the major source of heterogeneity across the studies. The pooled analysis did not suggest the significant association of IL‐1B 31 C>T polymorphism with gastric cancer risk. Stratified analysis was performed by ethnicity, source of control, genotype method, and indicated a significantly increased gastric cancer risk associated with IL‐1B 31T variant in the population‐based subgroup (heterozygous model: OR = 1.22, 95% CI = 1.03–1.45). Moreover, stratified analysis by Helicobacter pylori infection status indicated that IL‐1B 31 polymorphism increased gastric cancer risk in infection‐positive subgroup (homozygous model: OR = 1.35, 95% CI = 1.02–1.78; heterozygous model: OR = 1.31, 95% CI = 1.04–1.66; recessive model: OR = 1.29, 95% CI = 1.04–1.61). The study suggested that IL‐1B 31 polymorphism might confer susceptibility to gastric cancer in the presence of H. pylori infection, indicating a gene–environment interaction in gastric carcinogenesis.

show abstract

“…These fi ndings suggest that genetic polymorphisms in IL-8, IL-10, and TNF-α may play important roles in developing gastric cancer in the Chinese population. YANG et al (51) reported that, in Chinese population, the risks associated with the IL-1β variant genotypes were 1.64 for -31TT and 1.52 for -511CC, respectively, compared with their wildtype homozygotes. The risks were signifi cantly more evident in individuals with H. pylori infection, which was consistent with the biological effects of IL-1β.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

Araújo‐Filho

Brandão-Neto

Pinheiro

et al. 2006

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population

Cited by 77 publications

References 24 publications

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Prevalence of Helicobacter pylori infection in advanced gastric carcinoma

Contact Info

Product

Resources

About