Interleukin-1β and tumor necrosis factor-α in children with major depressive disorder or dysthymia

Brambilla, F; Monteleone, Palmiero; Maj, Małgorzata

doi:10.1016/s0165-0327(02)00315-4

Cited by 92 publications

(62 citation statements)

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“…[1][2][3] (2) Elevated levels of inflammatory markers, particularly IL-1, in patients with major depression or minor depression (dysthymia), which are correlated with the severity of depression, the duration of the current depressive episode and the age of disease onset. [3][4][5][6][7][8][9] (3) Induction of depressive symptoms in cytokine-treated cancer and hepatitis-C patients, which can be reversed by antidepressant treatment. 10,11 (4) Genetic association between genes of inflammatory factors, including polymorphisms in IL-1 family genes, and severity of depression and its responsiveness to antidepressant treatment.…”

Section: Introductionmentioning

confidence: 99%

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

et al. 2007

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Several lines of evidence implicate the pro-inflammatory cytokine interleukin-1 (IL-1) in the etiology and pathophysiology of major depression. To explore the role of IL-1 in chronic stress-induced depression and some of its underlying biological mechanisms, we used the chronic mild stress (CMS) model of depression. Mice subjected to CMS for 5 weeks exhibited depressive-like symptoms, including decreased sucrose preference, reduced social exploration and adrenocortical activation, concomitantly with increased IL-1b levels in the hippocampus. In contrast, mice with deletion of the IL-1 receptor type I (IL-1rKO) or mice with transgenic, brain-restricted overexpression of IL-1 receptor antagonist did not display CMS-induced behavioral or neuroendocrine changes. Similarly, whereas in wild-type (WT) mice CMS significantly reduced hippocampal neurogenesis, measured by incorporation of bromodeoxyuridine (BrdU) and by doublecortin immunohistochemistry, no such decrease was observed IL-1rKO mice. The blunting of the adrenocortical activation in IL-1rKO mice may play a causal role in their resistance to depression, because removal of endogenous glucocorticoids by adrenalectomy also abolished the depressive-like effects of CMS, whereas chronic administration of corticosterone for 4 weeks produced depressive symptoms and reduced neurogenesis in both WT and IL-1rKO mice. The effects of CMS on both behavioral depression and neurogenesis could be mimicked by exogenous subcutaneous administration of IL-1b via osmotic minipumps for 4 weeks. These findings indicate that elevation in brain IL-1 levels, which characterizes many medical conditions, is both necessary and sufficient for producing the high incidence of depression found in these conditions. Thus, procedures aimed at reducing brain IL-1 levels may have potent antidepressive actions.

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Section: Introductionmentioning

confidence: 99%

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

et al. 2007

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“…pre-pubertal and post-pubertal) in the studies. The youngest study participant was 6 years old in the Brambilla et al study (183), and 7 years old (median age 9.3 years) in Caserta et al (144).…”

Section: Differences In the Role Of Cytokines In Depression Between Amentioning

confidence: 94%

“…individuals in the Brambilla et al study (183), and 45 individuals in the studies by Gabbay et al (161,191)). In addition to small sample sizes, there are a range of ages of study participants (i.e.…”

Section: Differences In the Role Of Cytokines In Depression Between Amentioning

confidence: 96%

“…In adults with MDD, NK cell activity has been found to be decreased (170)(171)(172), however in adolescents with MDD, NK cell activity has been found to be increased (176), unchanged (177), and decreased (174). The elevated levels of IL-1β seen in adults with MDD have not been found in adolescents (183). Decreased levels of TNF-α have been found in adolescents with MDD (191), however many studies in adults (including a meta-analysis) have found elevated levels of TNF-α in MDD (6,(184)(185)(186)(187).…”

mentioning

confidence: 96%

“…and TNF-α (177,183,191,197). In adults with MDD, NK cell activity has been found to be decreased (170)(171)(172), however in adolescents with MDD, NK cell activity has been found to be increased (176), unchanged (177), and decreased (174).…”

mentioning

confidence: 98%

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The role of cytokines and inflammatory markers in depression in adolescents

Mills¹

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Aims: The overarching hypothesis is that circulating levels of pro-inflammatory cytokines and other inflammatory markers are genetically associated with depression in adolescents.Specifically, it is hypothesised that there will be a correlation between variation in genetic risk of depression and genetic variation of circulating pro-inflammatory cytokines and inflammatory markers. Methods:A systematic review of the literature was conducted to establish the current understanding of the relationship between inflammatory markers and depression in adolescents and to inform study design. Multiple approaches (including different types of genetic analyses and multiple data sets) were used to address the overarching hypothesis.A pilot study measuring cytokines, inflammatory markers, and other biomarkers involved in immune regulation (including Vitamin D, antibodies to infectious agents, and gliadin antibodies (found in coeliac disease)) was conducted in 107 monozygotic (MZ) and 160 dizygotic (DZ) twin pairs (mean age 16.2 years, standard deviation (SD) 0.25 years) from the Brisbane Adolescent Twin Study. A clinical study was undertaken to collect biological samples and clinical data from an in-patient adolescent mental health unit. Investigation of the relationship between iron measures (altered in inflammatory states)and measures of depression was undertaken in community cohorts of twins and their parents (3,416 adolescents from 1,688 families, and 9,035 adults from 4,533 families). In the adolescent cohort, depressive measures were assessed through the Somatic and Psychological Health Report (SPHERE) (mean age 15.1 years (SD 3.2 years)). In the adult cohort, a quantitative score of depression was measured by the Delusions Symptoms State Inventory (DSSI) (mean age 23.2 years (SD 2.2 years)). Heritabilities of, and phenotypic and genetic correlations between, traits were estimated. Association analyses, genetic profile risk score analyses, and LD score analyses were also used to investigate the genetic relationship between the iron and depression measures. Genetic profile risk score analyses were used to explore the genetic relationship between these variables. Results:In the pilot study, cytokines that were successfully measured in plasma were found to be moderately heritable (transforming growth factor-β1 (TGFβ1), 0.57 (95% CI 0.26 -0.80) and tumour necrosis factor-receptor type 1 (TNFR1), 0.50 (95% CI 0.11-0.63)). A negative correlation between Vitamin D and the cytokine IL-18 (-0.14) was not statistically significant (p=0.054). However, major difficulties were encountered in measuring cytokines, in particular due to the low levels of circulating cytokines in healthy adolescents. Challenges were also encountered in the cytokines study of the clinical sample of adolescents, which were able to be broadly divided into patient factors, blood collection factors, and other data collection factors.Iron measures were found to be highly heritable in both adolescents and adults: The relationship between CRP and Major D...

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Immunology and Developmental Psychopathology

Granger¹,

Granger²

2015

Developmental Psychopathology

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Interleukin-1β and tumor necrosis factor-α in children with major depressive disorder or dysthymia

Cited by 92 publications

References 30 publications

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression

The role of cytokines and inflammatory markers in depression in adolescents

Immunology and Developmental Psychopathology

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