Interleukin‐1β augments the angiogenesis of endothelial progenitor cells in an NF‐κB/CXCR7‐dependent manner

Abstract

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Local delivery of simvastatin maintains tooth anchorage during mechanical tooth moving via anti‐inflammation property and AMPK/MAPK/NF‐kB inhibition

“…NF-κB is a well-known transcription factor associated with inflammation and bone resorption. 51 Many studies reported orthodontic mechanical stress could trigger the NF-κB pathway activation, which mediated the expression of pro-inflammatory genes such as TNF-α and IL-6, as proved in our histological findings. 52 Therefore, inhibition of NF-κB activation is an important process in increasing tooth anchorage.…”

Increased expression of homeobox 5 predicts poor prognosis: A potential therapeutic target for glioma

“…Angiogenesis is one of the characteristics of malignant glioma, contributing to tumor proliferation and unfavorable prognosis [34]. The activation of the in ammatory response and IL6/JAK-STAT3 signaling pathway has been shown to play important roles in promoting this process [35,36]. In the present study, the multiple functional analysis of HOXB5-corelated genes revealed a signi cant association between HOXB5 and the regulation of angiogenesis, in ammatory response, and the IL6/JAK-STAT3 pathway.…”

FGF21 promotes ischaemic angiogenesis and endothelial progenitor cells function under diabetic conditions in an AMPK/NAD+‐dependent manner

“…The research ethics committee of the First Affiliated Hospital of Wenzhou Medical University approved all protocols, and informed consent was obtained from the parents of the newborns. EPCs were isolated as described in previous studies 17‐19 . Briefly, cord blood was diluted 1:1 with Hanks' balanced salt solution (HBSS; Invitrogen), carefully overlaid onto an equivalent volume of Histopaque 1077 (Sigma) and centrifuged at 400 g for 30 minutes at room temperature.…”

“…EPCs were isolated as described in previous studies. [17][18][19] Briefly, cord blood was diluted 1:1 with Hanks' balanced salt solution (HBSS; Invitrogen), carefully overlaid onto an equivalent volume of Histopaque 1077 (Sigma) and centrifuged at 400 g for 30 minutes at room temperature. Thereafter, the buffy coat was collected and washed with HBSS twice, and cell aggregate was resuspended in EGM-2 (Lonza) supplemented with 2% FBS (Sigma) and plated onto 6-well plates that were pre-coated with human fibronectin (2 μg/ cm 2 ; BD Biosciences).…”

“…Considering the critical role of EPCs in angiogenesis and the capability of FGF21 to promote EPC mobilization in T1DM, we hypothesized that the FGF21 improvement of blood perfusion and angiogenesis in diabetic ischaemia may have a direct protective effect on diabetic EPC functions. To test this hypothesis, the EPCs were isolated from human cord blood as previously described 19 and characterized by flow cytometry to distinguish EPCs, which are positive for CD144, CD34 and VEGFR2 and negative for CD14 or CD45 (Figure S1). As FGF21 exerts its biological functions by binding to its receptor FGFR1 and coreceptor KLB, 22 FGF21 receptor expression on EPCs was investigated by qRT-PCR.…”