Interleukin-1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms and gastric cancer risk in an Omani Arab population

Al-Moundhri, Mansour; Al-Nabhani, M.; Bahrani, Bassim Al; Burney, Ikram A.; Al-Madhani, Ali; Ganguly, Shyam S.; Al‐Yahyaee, Said; Grant, Christopher S.

doi:10.1007/s10120-006-0392-5

Cited by 32 publications

(35 citation statements)

References 27 publications

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“…Of the remaining 38 publications, three were eliminated, due to reporting duplicate data 17, 18, 19. Ultimately, 37 studies from 35 publications 6, 10, 14, 15, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50 including 6108 cases and 8980 controls were included in the meta‐analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…2 and Table 2). Upon the removal of studies 10, 14, 34, 38, 43, 46, 50 deviated from HWE, risk estimates were not substantially changed (homozygous model: OR = 1.05, 95% CI = 0.89–1.24; heterozygous model: OR = 1.07, 95% CI = 0.94–1.22; dominant model, OR = 1.08, 95% CI = 0.95–1.23 and recessive model: OR = 1.04, 95% CI = 0.92–1.18). Stratified analysis by ethnicity and source of control observed significant association among PB‐based studies under the heterozygous model (OR = 1.22, 95% CI = 1.03–1.45; Fig.…”

Section: Resultsmentioning

confidence: 99%

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Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Hua-yong

Zong³

et al. 2016

J Cellular Molecular Medi

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Gastric cancer is one of the most common malignancies worldwide. Interleukin‐1‐beta (IL‐1β) is a pro‐inflammatory cytokine and potent inhibitor of gastric acid secretion. Some studies provided evidence of the association between IL‐1B 31 polymorphism and gastric cancer risk while other studies did not. Therefore, we conducted a comprehensive meta‐analysis to reassess the association. A systematic literature search of the PubMed and EMBASE databases identified 37 studies with 6108 cases and 8980 controls for this meta‐analysis. The crude odd ratios (ORs) and the 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Meta‐regression was used to determine the major source of heterogeneity across the studies. The pooled analysis did not suggest the significant association of IL‐1B 31 C>T polymorphism with gastric cancer risk. Stratified analysis was performed by ethnicity, source of control, genotype method, and indicated a significantly increased gastric cancer risk associated with IL‐1B 31T variant in the population‐based subgroup (heterozygous model: OR = 1.22, 95% CI = 1.03–1.45). Moreover, stratified analysis by Helicobacter pylori infection status indicated that IL‐1B 31 polymorphism increased gastric cancer risk in infection‐positive subgroup (homozygous model: OR = 1.35, 95% CI = 1.02–1.78; heterozygous model: OR = 1.31, 95% CI = 1.04–1.66; recessive model: OR = 1.29, 95% CI = 1.04–1.61). The study suggested that IL‐1B 31 polymorphism might confer susceptibility to gastric cancer in the presence of H. pylori infection, indicating a gene–environment interaction in gastric carcinogenesis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Hua-yong

Zong³

et al. 2016

J Cellular Molecular Medi

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“…The promoter polymorphism of TNFA-308 play important role in H. pylori-induced gastritis and also has been found to influence the risk of gastric cancer (Bhayal et al, 2013). The current theory describing the risk of atrophic gastritis caused by H. pylori infection does not always work in studies performed in different ethnic groups and geographic regions (Santtila et al, 1998;Figueiredo et al, 2002;Peek and Blaser, 2002;Hsu et al, 2004;Garza-Gonzalez et al, 2005;Perez-Perez et al, 2005;Al-Moundhri et al, 2006;Moorchung et al, 2007).…”

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confidence: 99%

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

Kulmambetova¹,

Imanbekova²,

Logvinenko³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Многими учеными было установлено, что полимор-физм генов ИЛ-1В и ИЛ-1RN обусловливает воспаление и атрофию слизистой оболочки желудка, способствует канцерогенезу [40][41][42][43][44][45][46][47]. Так, при обследовании родствен-ников больных раком желудка было выявлено, что с нали-чием полиморфных вариантов ИЛ-1В -511/-31, ИЛ-1RN 2/2 значительно возрастает риск гипохлоргидрии и желу-дочной атрофии в присутствии H. pylori.…”

Section: про-и противоонкогенное действие цитокинов семейства ил-1unclassified

“…Al-Moundhri и соавт. выявили, что полимор-физм гена ИЛ-1RN повышает риск развития рака желудка в арабской популяции, особенно у пациентов, инфици-рованных H. pylori [43]. Установлено, что характерная для R2/R2-генотипа высокая продукция ИЛ-1Ra подавляет провоспалительные эффекты ИЛ-1β, содержание кото-рого начинает повышаться по принципу отрицательной обратной связи, что в свою очередь увеличивает акти-вацию ИЛ-1Ra [7].…”

Section: про-и противоонкогенное действие цитокинов семейства ил-1unclassified

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

Матвеева

Мосина

2012

Annals RAMS

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Interleukin-1β gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms and gastric cancer risk in an Omani Arab population

Cited by 32 publications

References 27 publications

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Interleukin‐1B 31 C>T polymorphism combined with Helicobacter pylori‐modified gastric cancer susceptibility: evidence from 37 studies

Association of Cytokine Gene Polymorphisms with Gastritis in a Kazakh Population

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

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