Interleukin-1β has excitatory effects on neurons of the bed nucleus of the stria terminalis

Mf, Wilkinson; Wb, Mathieson; Pittman, Quentin J.

doi:10.1016/0006-8993(93)91079-8

Cited by 24 publications

(11 citation statements)

References 23 publications

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“…This possibility deserves further study. The AP is not enriched in IL-l receptors, but neither are any of the other brain sites that have been shown to be responsive to locally applied IL-1 (Tsagarakis et al, 1989;Wilkinson et al, 1993). Within the PVN, c-fos mRNA levels were increased at 1 and 3 hr (Table 2).…”

Section: Discussion Endocrine Parametersmentioning

confidence: 83%

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

et al. 1994

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This study was designed to examine the mechanisms by which systemic interleukin-1 affects neuroendocrine systems in the brain. Intraperitoneal injections of interleukin-1 beta (1.25 micrograms/rat) were administered to rats. One or three hours after injection, the expression levels of the immediate-early gene c-fos and of genes for several neuropeptides, receptors, and enzymes were examined by in situ hybridization histochemistry. In the brainstem at 1 hr, c-fos mRNA was elevated in the area postrema and nucleus of the solitary tract, but not in the locus coeruleus. At 3 hr, the c-fos mRNA levels had increased further in the nucleus of the solitary tract. Rostrally, elevations in c-fos mRNA levels were found in the hypothalamic and thalamic paraventricular nuclei, central nucleus of amygdala, bed nucleus of the stria terminalis, and medial preoptic area, peaking at 1 hr and diminishing at 3 hr. In addition, at 3 hr a new pattern of c-fos activity emerged--the arcuate nucleus and cells at the external margins throughout the brain now expressed c-fos mRNA. Corticotropin-releasing hormone mRNA levels were doubled in the paraventricular nucleus at 1 and 3 hr, concomitant with elevations in plasma adrenocorticotrophic hormone (ACTH) and corticosterone. Tyrosine hydroxylase mRNA levels in the brainstem did not change. The c-fos mRNA induction patterns reveal a temporally dynamic response to interleukin-1 administration. We propose that the early set of structures responding to interleukin-1 initiates the neuroendocrine response to cytokines. Coactivation of the area postrema and nucleus of the solitary tract may reflect entry into the brain and neural transduction of the peripheral signal. The late set--including the nucleus of the solitary tract, arcuate nucleus, and the brain's edge--may reflect cellular activation along the diffusion routes traveled by interleukin-1 or a bioactive transduction product, because the pattern of edge labeling is similar to the autoradiographic pattern of flow lf radiolabeled tracer substances in the cerebrospinal fluid. The late c-fos mRNA response to interleukin-1, therefore, may represent a demonstration of information transfer in the parasynaptic mode, also known as volume transmission.

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Section: Discussion Endocrine Parametersmentioning

confidence: 83%

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

et al. 1994

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“…Interactive effects of stress, CRF, and TNFα are arguably mediated by interaction of glia and neurons (Adler et al, 2006; Rostène et al, 2007; Kawasaki et al 2008; Wilkinson et al 1993). In this regard, a likely source of cytokine input following stress is the activation of glia (Bajetto et al, 2002), which when activated release cytokines including TNFα and IL1β (Kreutzberg, 1996).…”

Section: Discussionmentioning

confidence: 99%

Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety

Knapp¹,

Whitman²,

Wills³

et al. 2011

Brain, Behavior, and Immunity

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Stress has been shown to facilitate ethanol withdrawal-induced anxiety. Defining neurobiological mechanisms through which stress has such actions is important given the associated risk of relapse. While CRF has long been implicated in the action of stress, current results show that stress elevates the cytokine TNFα in the rat brain and thereby implicates cytokines in stress effects. In support of this view, prior TNFα microinjection into the central amygdala (CeA) of rats facilitated ethanol withdrawal-induced anxiety—a response that could not be attributed to an increase in plasma corticosterone. To test for a possible interaction between cytokines and CRF, a CRF1-receptor antagonist (SSR125543) administered prior to the repeated administration of TNFα or MCP-1/CCL2 reduced the magnitude of the withdrawal-induced anxiety. This finding provided evidence for cytokine action being dependent upon CRF. Additionally, the sensitizing effect of stress on withdrawal-induced anxiety was reduced by treating the repeated stress exposure prior to ethanol with the MEK inhibitor SL327. Consistent with cytokines having a neuromediator function distinct from a neuroimmune action, TNFα increased firing rate and GABA release from CeA neurons. Thus, an interaction of glial and neuronal function is proposed to contribute to the interaction of stress and chronic ethanol. Interrupting this potential glial-neuronal interaction could provide a novel means by which to alter the development of emotional states induced by stress that predict relapse in the alcoholic.

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“…These effects may be mediated by the fast activation of the Nsphingomyelinase (N-Smase) and ceramide production (Mathias and Kolesnick, 1993;Nalivaeva et al, 2000). They are PGE2 independent and rapidly change the firing rates of neurons following binding of IL-1β to its receptor (Hori et al, 1988;Sanchez-Alavez et al, 2006;Wilkinson et al, 1993). Although the signaling molecules involved in the action of IL-1β upon defensive rage have not been identified, the observation that the maximum effect was observed at 60 minutes post injection suggests that the cyclooxygenase and PGE2 mediated pathway may be involved in IL-1β mediated potentiation of defensive rage in the cat.…”

Section: Discussionmentioning

confidence: 99%

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Bhatt

Zalcman

et al. 2008

Brain, Behavior, and Immunity

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Feline defensive rage, a form of aggressive behavior that occurs in response to a threat can be elicited by electrical stimulation of the medial hypothalamus or midbrain periaqueductal gray (PAG). Our laboratory has recently begun a systematic examination of the role of cytokines in the regulation of rage and aggressive behavior. It was shown that the cytokine, interleukin-2 (IL-2), differentially modulates defensive rage when microinjected into the medial hypothalamus and PAG by acting through separate neurotransmitter systems. The present study sought to determine whether a similar relationship exists with respect to interleukin 1-β (IL-1β), whose receptor activation in the medial hypothalamus potentiates defensive rage. Thus, the present study identified the effects of administration of IL-1β into the PAG upon defensive rage elicited from the medial hypothalamus. Microinjections of IL-1β into the dorsal PAG significantly facilitated defensive rage behavior elicited from the medial hypothalamus in a dose and time dependent manner. In addition, the facilitative effects of IL-1β were blocked by pre-treatment with anti-IL-1β receptor antibody, while IL-1β administration into the PAG had no effect upon predatory attack elicited from the lateral hypothalamus. The findings further demonstrated that IL-1β's effects were mediated through 5-HT 2 receptors since pretreatment with a 5-HT 2C receptor antagonist blocked the facilitating effects of IL-1β. An extensive pattern of labeling of IL-1β and 5-HT 2C in the dorsal PAG supported these findings. The present study demonstrates that IL-1β in the dorsal PAG, similar to the medial hypothalamus, potentiates defensive rage behavior and is mediated through a 5-HT 2C receptor mechanism.

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Interleukin-1β has excitatory effects on neurons of the bed nucleus of the stria terminalis

Cited by 24 publications

References 23 publications

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain

Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

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