2006
DOI: 10.1667/rr3478.1
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Interleukin 1β (IL1B) Signaling is a Critical Component of Radiation-Induced Skin Fibrosis

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Cited by 89 publications
(61 citation statements)
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“…The involvement of IL-1 in fibrogenesis was also observed in experiments by Mancini et al (29), showing that treatment with an IL-1 receptor antagonist protects rats from dimethylnitrosamineinduced liver fibrosis. Furthermore, IL-1 has been associated with fibrosis in other organs, such as lungs and kidney (25,28,30,40). Similarly, increased TNF-␣ signaling, which shares many intracellular pathways with IL-1, is also associated with the onset of fibrosis (32).…”
Section: Discussionmentioning
confidence: 99%
“…The involvement of IL-1 in fibrogenesis was also observed in experiments by Mancini et al (29), showing that treatment with an IL-1 receptor antagonist protects rats from dimethylnitrosamineinduced liver fibrosis. Furthermore, IL-1 has been associated with fibrosis in other organs, such as lungs and kidney (25,28,30,40). Similarly, increased TNF-␣ signaling, which shares many intracellular pathways with IL-1, is also associated with the onset of fibrosis (32).…”
Section: Discussionmentioning
confidence: 99%
“…IL-1, which can be released by MCs on TLR triggering induces the synthesis of prostaglandins, important pain mediators and stimulates fibroblasts activation and proliferation, which contribute to fibrosis and adhesion formation by fibrinogen and subsequent collagen depositions [18,25]. Adhesions are frequently found in the area of endometriotic lesions [26,27].…”
Section: Mast Cells In Ems: a Painful Liaison?mentioning
confidence: 99%
“…Studies on radiation and burn injuries propose imbalances in the cytokine feedback as the underlying mechanism for RCI (45). Radiationinduced increases in IL-1 and transforming growth factor (TGF)β1 expressions are predictive of fibrovascular changes after high doses of radiation in several mouse strains and in human patients (46)(47)(48). These data suggest that therapies that reduce IL-1, IL-6 and/or TGFβ expression might change the fibrovascular effects of radiation exposure and thus enhance survival.…”
Section: Radiation and Thermal Injury (Burns) Or Woundsmentioning
confidence: 99%