Interleukin-1β mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway

Wang, Xiaofei; Fu, Sai-Li; Wang, Yanxia; Yu, Panpan; Hu, Jianguo; Gu, Wenli; Xu, Xiao–Ming; Lu, Peihua

doi:10.1016/j.mcn.2007.07.005

Cited by 123 publications

(97 citation statements)

References 47 publications

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“…However, neural progenitors derived from the embryonic rat brain, which were expanded in neurospheres, did not express IL-1ra. In contrast, IL-1ra inhibited GFAP (glial fibrillary acidic protein) expression in differentiated astrocytes [18]. This correlates well with the reduced expression of GFAP in dedifferentiated MCs [8].…”

Section: Proteins Up-regulated In Mcssupporting

confidence: 54%

Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Müller Cells

et al. 2011

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Unrelated cells such as dental follicle precursor cells (DFPCs) and retinal Müller cells (MCs) make spheres after cultivation in serum-replacement medium (SRM). Until today, the relation and molecular processes of sphere formation from different cell types remain undescribed. Thus in this study we compared proteomes of spheres derived from MCs and DFPCs. 73% of 676 identified proteins were similar expressed in both cell types and many of them are expressed in the brain (55%). Moreover proteins are overrepresented that are associated with pathways for neural diseases such as Huntington disease or Alzheimer disease. Interestingly up-regulated proteins in DFPCs are involved in the biosynthesis of glycosphingolipids. These lipids are components of gangliosides such as GD3, which is a novel neural stem cell marker. In conclusion spheres from different types of cells have highly similar proteomes. These proteomes probably show essential cellular processes in neurosphere-like cell clusters.

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Section: Proteins Up-regulated In Mcssupporting

confidence: 54%

Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Müller Cells

et al. 2011

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“…JNK signaling has been shown to mediate FGF2-stimulated proliferation of embryonic neural stem cells (61). JNK signaling is also involved in differentiation and apoptosis of neural stem cells (62)(63)(64). In contrast, p38MAPK signaling in neural stem cell regulation has been less characterized.…”

Section: Discussionmentioning

confidence: 99%

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade

Zhang

Guo

Zhang

et al. 2011

Journal of Biological Chemistry

113

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“…In vitro exposure of embryonic rat brain NPCs to IL-1β inhibits their proliferation through apparent apoptosis induced by excess IL-1β (22). Conversely, others reported that IL-1β increases the proliferation of fetal human NPCs and inhibits their differentiation into neurons (21).…”

Section: Il-1β and Il-6mentioning

confidence: 97%

Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration

et al. 2011

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Abstract. Adult neurogenesis is the process of generating new neurons that become integrated into existing circuits after fetal and early postnatal development has ceased. In most mammalian species, adult neurogenesis only appears to occur in the olfactory bulb and the hippocampus, where neural stem/progenitor cells (NPCs) exist to create new neurons. In adult neurogenesis, microenviromental change is thought to provide a specific modulation for maintaining the multi-potent state of these NPCs. Neurodegeneration is driven by the activation of resident microglia, astrocytes, and infiltrating peripheral macrophages, which release a plethora of cytokines, chemokines, neurotransmitters, and reactive oxygen species. These endogenous factors cause further bystander damage to neurons and produces both detrimental and favorable conditions for neurogenesis. Interestingly, these endogenous factors also affect the proliferation, migration, differentiation, and survival of the NPCs, as well as regulate the incorporation of newly formed neurons into the brain circuitry. The unique profile of the endogenous factors released can vary the degree of neuroregeneration after neurodegeneration. This current review summarizes recent knowledge in the emerging field that is showing that adult neurogenesis is regulated by endogenous factors produced during neurodegeneration.

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Interleukin-1β mediates proliferation and differentiation of multipotent neural precursor cells through the activation of SAPK/JNK pathway

Cited by 123 publications

References 47 publications

Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Müller Cells

Comparison of Neurosphere-like Cell Clusters Derived from Dental Follicle Precursor Cells and Retinal Müller Cells

Adiponectin Stimulates Proliferation of Adult Hippocampal Neural Stem/Progenitor Cells through Activation of p38 Mitogen-activated Protein Kinase (p38MAPK)/Glycogen Synthase Kinase 3β (GSK-3β)/β-Catenin Signaling Cascade

Adult Neurogenesis Is Regulated by Endogenous Factors Produced During Neurodegeneration

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