Interleukin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan

Furuta, Takahisa; El‐Omar, Emad; Xiao, Fang; Shirai, Naohito; Takashima, Misako; Sugimurra, Haruhiko

doi:10.1053/gast.2002.34156

Cited by 330 publications

(292 citation statements)

References 34 publications

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“…The mucosal IL-1␤ levels were expressed as picograms of cytokine per milligram of biopsy protein (pg/mg protein). 27 …”

Section: Il-1␤ Cytokine Measurement In Gastric Mucosamentioning

confidence: 99%

“…25 Furthermore, another recent study showed that an H. pylori-positive group with IL-1B-511T/T genotype had higher gastric secretion pH, lower pepsinogen I/pepsinogen II ratios, higher gastric atrophy and gastritis scores compared with those of C/T and C/C groups. 27 In this study, we investigated the effects of IL-1 genetic polymorphism on IL-1␤ production in the gastric corpus mucosa. The subjects included H. pylori-infected and H. pylori-noninfected controls and GC patients.…”

Section: Il-1b-31 Il-1b-511mentioning

confidence: 99%

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Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Chang

Jang

Kim

et al. 2004

Intl Journal of Cancer

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Interleukin-1B and IL-1 receptor antagonist gene polymorphisms are associated with an increased risk of gastric cancer (GC) in Caucasian populations. However, recent studies could not find any association between IL-1B-511T polymorphism and the risk of GC in Asians. We tested for an association between IL-1 loci polymorphisms with increased gastric mucosal levels of IL-1␤ and an increased risk of developing GC in a Korean population. Polymorphisms of IL-1A-889, IL-1B-31, IL-1B-511 and IL-1RN were genotyped in 434 controls and 234 patients with GC. Mucosal IL-1␤ cytokine was measured using an ELISA. The frequencies of IL-1A, IL-1B-511, IL-1B-31 and IL-1RN were not statistically different between controls and all patients with GC. After subclassification of GC, only patients with intestinal-type GC showed a higher frequency of IL-1B-31T homozygotes (OR ‫؍‬ 2.2; 95% CI ‫؍‬ 1.1-4.3) compared with controls. Risk was also significantly increased in these patients for IL-1B-31T homozygotes compared with patients with diffuse-type GC (OR ‫؍‬ 3.4; 95% CI ‫؍‬ 1.5-7.7). As in Caucasian populations, linkage disequilibrium between IL-1B-31 and IL-1B-511 was nearly complete, but the pattern of haplotype related to the risk of GC (IL-1B-31T/IL-1B-511C) was opposite (IL-1B-511T/IL-1B-31C). Mucosal IL-1␤ levels in H. pylori-infected GC patients were higher in patients homozygous for IL-1B-31T compared with IL-1B-31C/T and IL-1B-31C/C. Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1␤ production contributed to the development of intestinal-type GC in this Korean population.

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“…The mucosal IL-1␤ levels were expressed as picograms of cytokine per milligram of biopsy protein (pg/mg protein). 27 …”

Section: Il-1␤ Cytokine Measurement In Gastric Mucosamentioning

confidence: 99%

Section: Il-1b-31 Il-1b-511mentioning

confidence: 99%

Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Chang

Jang

Kim

et al. 2004

Intl Journal of Cancer

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“…of gastric cancer, it has been shown that the same markers increase the risk of premalignant changes in H. pylori infected subjects. 24,25 Another important consideration when studying the role of a particular host genetic marker is whether this genetic marker is being influenced by environmental exposures and whether it is acting in concert with other genetic factors. For example, it is known that the presence of other proinflammatory cytokine gene polymorphisms could enhance significantly the risk of developing GC.…”

Section: Il-1b-31(c/t) Tnf-a-308mentioning

confidence: 99%

Role of the polymorphic IL‐1B, IL‐1RN and TNF‐A genes in distal gastric cancer in Mexico

Garza‐González

Bosques-Padilla

El-Omar

et al. 2004

Intl Journal of Cancer

110

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“…8 In fact, recently IL1B and IL1RN (interleukin-1 receptor antagonist) proinflammatory genotypes have been associated with an increased risk for hypochlorhydria, severe gastric lesions and the development of gastric carcinoma in both Caucasian and Asian populations. [9][10][11][12][13][14][15] Carriers of the polymorphic allele with a C instead of a T at position À31 of a regulatory region of the IL1B gene are thought to overexpress gastric IL-1b in response to H. pylori infection that amplifies the inflammation and increases gastric lesion. Furthermore, IL-1b is a powerful gastric acid inhibitor and increased gastric levels of IL-1b may cause hypochlorhydria.…”

mentioning

confidence: 99%

IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma

Rocha

Guerra

Rocha

et al. 2005

Intl Journal of Cancer

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Helicobacter pylori cagA-positive strains and host cytokine proinflammatory polymorphisms have been associated with gastric carcinoma. However, the individual role of each factor has not been evaluated yet. Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-a (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian population by analyzing the data in logistic regression models. We evaluated 166 patients with noncardia gastric carcinoma and 541 blood donors. Among them, 702 were successfully genotyped for all cytokine studied: 166 with gastric carcinoma and 536 controls. The carcinoma patients were considered to be H. pylori-positive if culture alone or 2 among preformed urease test, stained smear or histologic section, serology, polymerase chain reaction (PCR) for ureA and urea breath test were positive. In blood donors, H. pylori status was based on enzyme-linked immunosorbent assay. The cagA status was determined by PCR or serology. IL1B-511/-31, IL1RN (interleukin-1 receptor antagonist) and TNFA-307 polymorphisms were genotyped by PCR, PCR with restriction fragment length polymorphism, or PCR with confronting 2-pair primers. We found that the IL1RN2 polymorphic allele (OR 5 1.93) was associated with noncardia gastric carcinoma, even after inclusion of age, gender and cagA status in the logistic models. However, the cagA-positive status was the strongest independent factor associated with gastric carcinoma (OR 5 11.89). The other polymorphisms were not significantly associated with the disease when they were evaluated in logistic models. This study provides evidence supporting the independent associations of cagA-positive H. pylori status and IL1RN polymorphisms with noncardia gastric carcinoma. ' 2005 Wiley-Liss, Inc.

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Interleukin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan

Cited by 330 publications

References 34 publications

Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Interleukin‐1B (IL‐1B) polymorphisms and gastric mucosal levels of IL‐1β cytokine in Korean patients with gastric cancer

Role of the polymorphic IL‐1B, IL‐1RN and TNF‐A genes in distal gastric cancer in Mexico

IL1RN polymorphic gene and cagA‐positive status independently increase the risk of noncardia gastric carcinoma

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