Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Wu, Guojin; Zhang, Yueyan; Niu, Linlin; Hu, Yuan; Yang, Yuting; Zhao, Yao

doi:10.1016/j.virusres.2024.199344

Virus Research

2024

DOI: 10.1016/j.virusres.2024.199344

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Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Guojin Wu,

Yueyan Zhang,

Linlin Niu

et al.

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The role of respiratory infections in the formation of airway hyperresponsiveness in children

Manukyan,

Prikhodko

2024

Bûlletenʹ fiziologii i patologii dyhaniâ

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Airway hyperresponsiveness (AHR) is a heterogeneous and complex disorder characterized by excessive narrowing of the airways in response to various exogenous and endogenous stimuli. This article presents information from the last five years, including 50 publications from PubMed and Google Scholar, on the most common viruses that provoke the development of airway hyperresponsiveness in children, including respiratory syncytial virus, rhinovirus, metapneumovirus, influenza and parainfluenza viruses, SARS-CoV-2 coronavirus, adenovirus, and bocavirus. It describes a number of pathophysiological mechanisms by which viruses damage the respiratory epithelium and lead to the formation of infectious and post-infectious bronchial hypersensitivity. The role of hyperexpression of cytokines and inflammatory mediators in the development of AHR, especially in early childhood, is emphasized. It is shown that the inflammatory process and a balanced immune response are crucial for mitigating the severity of the disease caused by viruses. Understanding the molecular mechanisms of inflammatory reactions and the immune response to acute respiratory viral infections can help develop more effective methods for the prevention and treatment of respiratory diseases in children.

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The role of respiratory infections in the formation of airway hyperresponsiveness in children

Manukyan,

Prikhodko

2024

Bûlletenʹ fiziologii i patologii dyhaniâ

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Interleukin-1β promotes human metapneumovirus replication via activating the cGAS-STING pathway

Cited by 1 publication

References 40 publications

The role of respiratory infections in the formation of airway hyperresponsiveness in children

The role of respiratory infections in the formation of airway hyperresponsiveness in children

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