1995
DOI: 10.1038/bjc.1995.16
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Interleukin 2-induced increase of vascular permeability without decrease of the intravascular albumin pool

Abstract: Interleukin 2 (IL-2) exhibits anti-tumour activity. High-dose IL-2 regimens are limited by side-effects such as pulmonary oedema and a systemic vascular leak. The mechanisms by which IL-2 mediates transvascular fluid and protein losses in humans are largely unknown. We have, therefore, measured the transcapillary escape rate (TER) of albumin as a reflection of the vascular permeability by injecting [125I]albumin (5 microCi i.v.). In ten melanoma patients pretreated with interferon alpha (IFN-alpha) TER of albu… Show more

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Cited by 41 publications
(16 citation statements)
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“…Because Hoechst 33342 staining used as an indicator of vascular perfusion (28) was increased in the tumors of mice treated with paclitaxel, we hypothesized an increase of tumor perfusion. Surprisingly, although IL2 had previously been shown to increase vascular permeability in patient healthy tissue and in tumor-bearing mice (29,30), a similar effect was not observed in our studies when the fusion protein F8-IL2 was used as single agent. The resistance of tumor tissue to IL2-induced increase vascular permeability could be expression of the angiogenic phenotype of tumor endothelial cells (more resistant to IL2 direct toxic effect) or to the different cytokine milieu of tumor tissue.…”
Section: Discussioncontrasting
confidence: 40%
“…Because Hoechst 33342 staining used as an indicator of vascular perfusion (28) was increased in the tumors of mice treated with paclitaxel, we hypothesized an increase of tumor perfusion. Surprisingly, although IL2 had previously been shown to increase vascular permeability in patient healthy tissue and in tumor-bearing mice (29,30), a similar effect was not observed in our studies when the fusion protein F8-IL2 was used as single agent. The resistance of tumor tissue to IL2-induced increase vascular permeability could be expression of the angiogenic phenotype of tumor endothelial cells (more resistant to IL2 direct toxic effect) or to the different cytokine milieu of tumor tissue.…”
Section: Discussioncontrasting
confidence: 40%
“…A significant toxic side effect of IL-2 therapy involves the circulatory system; sufficiently high doses of IL-2 can cause systemic vascular leak syndrome with accompanying cardiopulmonary and hematological complications [45,46]. It is possible that elevated levels of CRP in blood reflect not only on the inflammatory process, but on the amount of damaged or weakened tissues in the patient.…”
Section: Discussionmentioning
confidence: 99%
“…In severely-injured and critically-ill patients with a major inflammatory response there is leucocyte activation and increased microvascular permeability (Fleck et al 1985;Ballmer-Weber et al 1995;Plante et al 1995). Increased capillary permeability leads to a leak of plasma proteins, electrolytes and water from the intravascular compartment to the interstitial space.…”
Section: Stimulusmentioning
confidence: 99%