Interleukin-21 as an adjuvant in cancer immunotherapy: Current advances and future directions

Li, Xinyang; Wu, Meng; Lu, Jie; Yu, Jinming; Chen, Dawei

doi:10.1016/j.bbcan.2024.189084

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

2024

DOI: 10.1016/j.bbcan.2024.189084

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Interleukin-21 as an adjuvant in cancer immunotherapy: Current advances and future directions

Xinyang Li,

Meng Wu,

Jie Lu

et al.

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Immunoadjuvants in Cancer Immunotherapy

Talati,

Chouhan,

Sharma

et al. 2024

Advances in Medical Diagnosis, Treatment, and Care

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Immunoadjuvants are crucial components of cancer immunotherapy that enhance immune responses against tumors. This chapter explores the underlying mechanisms and clinical uses of immunoadjuvants in cancer immunotherapy. Toll-like receptor agonists and STING agonists are two types of immunoadjuvants that activate immune cells and promote anti-tumor immunity. Cytokine-based immunoadjuvants have potential toxicity and off-target effects, but nanotechnology enables precision delivery to minimize these issues. Personalized approaches, biomarker discovery, and predictive modeling are important for optimizing treatment responses. Overall, immunoadjuvants are essential tools in cancer immunotherapy for generating strong and long-lasting anti-tumor immune responses. In conclusion, immunoadjuvants are critical components of cancer immunotherapy, playing a vital role in boosting strong and durable anti-tumor immune responses.

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Immunoadjuvants in Cancer Immunotherapy

Talati,

Chouhan,

Sharma

et al. 2024

Advances in Medical Diagnosis, Treatment, and Care

View full text Add to dashboard Cite

show abstract

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Interleukin-21 as an adjuvant in cancer immunotherapy: Current advances and future directions

Cited by 1 publication

References 139 publications

Immunoadjuvants in Cancer Immunotherapy

Immunoadjuvants in Cancer Immunotherapy

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