Interleukin-23 as a therapeutic target for inflammatory myopathy

Umezawa, Natsuka; Kawahata, K.; Mizoguchi, Fumitaka; Kimura, Naoki; Yoshihashi-Nakazato, Yoko; Miyasaka, Nobuyuki; Kohsaka, Hitoshi

doi:10.1038/s41598-018-23539-4

Cited by 31 publications

(16 citation statements)

References 39 publications

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“…IL-17 and IL-23 levels were elevated in patients with early disease durations [73]. In a murine model of myositis, IL-23 played an important role in muscle damage [74]. A recent report showed successful use of ustekinumab, an anti-IL-12/23 p40 monoclonal antibody useful for psoriasis therapy, for refractory mechanic's hand in a patient with antisynthetase syndrome [75].…”

Section: Psoriasis and Dmmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

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Psoriasis is a chronic systemic inflammatory disease with various co-morbidities, having been recently considered as a comprehensive disease named psoriatic disease or psoriatic syndrome. Autoimmune diseases are one form of its co-morbidities. In addition to the genetic background, shared pathogenesis including innate immunity, neutrophil extracellular trap (NETs), and type I interferon, as well as acquitted immunity such as T helper-17 (Th17) related cytokines are speculated to play a significant role in both psoriasis and connective tissue diseases. On the other hand, there are definite differences between psoriasis and connective tissue diseases, such as their pathomechanisms and response to drugs. Therefore, we cannot expect that one stone kills two birds, and thus caution is necessary when considering whether the administered drug for one disease is effective or not for another disease. In this review, several connective tissue diseases and related diseases are discussed from the viewpoint of their coexistence with psoriasis.

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Section: Psoriasis and Dmmentioning

confidence: 99%

Psoriasis and Connective Tissue Diseases

Yamamoto

2020

IJMS

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“…It is important to denote that the implication of IL-17 and IL-23 in IIM has been previously reported, observed as an increment of both cytokines in the supernatant of the ex vivo culture of peripheral blood mononuclear cells of IIM patients with a recent disease establishment when compared with patients with established disease 42 . Likewise, it has been reported an increment of IL-23 serum levels in IIM patients as well as a higher expression of the cytokine in impaired muscle tissue, even IL-23 has been proposed as a therapeutic target for IIM treatment 43 .…”

Section: Discussionmentioning

confidence: 97%

Impaired muscle strength is associated with ultrastructure damage in myositis

Aguilar-Vazquez

Chavarria-Ávila

Salazar-Páramo

et al. 2022

Sci Rep

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The muscle fiber ultrastructure in Idiopathic Inflammatory Myopathies (IIM) has been scarcely explored, especially in Inclusion Body Myositis. The aim of this study was to implement the Scanning Electron Microscopy (SEM) in a small cohort of IIM patients, together with the characterization of immunological profile for a better understanding of the pathophysiology. For immunological profile characterization, we identified the presence of autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ, Mi-2α, Mi-2β) and quantified cytokines (IL-1β, IFN-α2, IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33) and chemokines (CCL2, CXCL8). The histological analysis was made by hematoxylin–eosin staining while the muscle fiber ultrastructure was characterized by SEM. We observed changes in the morphology and structure of the muscle fiber according to muscle strength and muscle enzymes. We were able to find and describe muscle fiber ultrastructure with marked irregularities, porosities, disruption in the linearity and integrity of the fascicle, more evident in patients with increased serum levels of muscle enzymes and diminished muscle strength. Despite the scarce reports about the use of SEM as a tool in all clinical phenotypes of IIM, our work provides an excellent opportunity to discuss and reframe the clinical usefulness of SEM in the diagnostic approach of IIM.

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“…It is important to denote that the implication of IL-17 and IL-23 in IIM has been previously reported as an increment of both cytokines in the supernatant of the ex vivo culture of peripheral blood mononuclear cells of IIM patients with a recent disease establishment when were compared with patients with established disease 43 . Likewise, it has been reported an increment of IL-23 serum levels in IIM patients as well as a higher expression of the cytokine in impaired muscle tissue, even IL-23 has been proposed as a therapeutic target for IIM treatment 44 .…”

Section: Discussionmentioning

confidence: 97%

Muscle fiber ultrastructure is associated with the immunological profile in idiopathic inflammatory myopathies.

Aguilar-Vazquez

Chavarria-Ávila

Salazar-Páramo

et al. 2022

Preprint

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The diagnosis and classification of Idiopathic Inflammatory Myopathies (IIM) remain complex because of the lack of information about their pathogeny. Scanning Electron Microscopy (SEM) allows a histological analysis with better resolution, which together with the immunological profile, is useful for a better understanding of physiopathology. For immunological profile characterization, we identified the presence of autoantibodies (Ro-52, OJ, EJ, PL7, PL12, SRP, Jo-1, PMScl75, PMScl100, Ku, SAE1, NXP2, MDA5, TIF1γ, Mi-2α, Mi-2β) and quantified cytokines (IL-1β, IFN-α2, IFN-γ, TNF-α, IL-6, IL-10, IL-12p70, IL-17A, IL-18, IL-23, IL-33) and chemokines (CCL2, CXCL8). The histological analysis was made by hematoxylin-eosin staining while the muscle fiber was characterized by SEM. We observed changes in the morphology and structure of the muscle fiber according to muscle strength and muscle enzymes. We were able to find and describe muscle fiber ultrastructure with marked irregularities, porosities, disruption in the linearity and integrity of the fascicle, more evident in patients with increased serum levels of muscle enzymes and diminished muscle strength. Even the scarce reports about the use of SEM as a tool in all clinical phenotypes of IIM, our work provides an excellent opportunity to discuss and reframe the clinical usefulness of SEM in the diagnostic approach of IIM.

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Interleukin-23 as a therapeutic target for inflammatory myopathy

Cited by 31 publications

References 39 publications

Psoriasis and Connective Tissue Diseases

Psoriasis and Connective Tissue Diseases

Impaired muscle strength is associated with ultrastructure damage in myositis

Muscle fiber ultrastructure is associated with the immunological profile in idiopathic inflammatory myopathies.

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