2023
DOI: 10.1002/eji.202250348
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Interleukin 23 receptor: Expression and regulation in immune cells

Ikram Mezghiche,
Hanane Yahia‐Cherbal,
Lars Rogge
et al.

Abstract: The importance of interleukin‐23 (IL‐23) and its specific receptor, IL‐23R, in the pathogenesis of several chronic inflammatory diseases has been established, but the underlying pathological mechanisms are not fully understood. This review focuses on IL‐23R expression and regulation.This article is protected by copyright. All rights reserved

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Cited by 8 publications
(1 citation statement)
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“…What induces Treg cells to express Il23r remains largely unknown. ( 11 ) Given that pro-inflammatory mediators such as IL-6 are involved in the polarization of naïve T cells towards IL-17 producing Th17 cells, which also upregulate Il23r for Th17 cell maintenance ( 12 ), we hypothesized that chronic inflammation may increase Il23r expression in colonic Treg cells. To experimentally test this, Il23r flox/+ Foxp3 YFP-iCre mice were subjected to three cycles of dextran sulfate sodium (DSS) for 5 days that were interrupted by a 10-day rest period each cycle to mimic the relapsing and remitting inflammation experienced by patients with IBD ( Figures 1A, B ).…”
Section: Resultsmentioning
confidence: 99%
“…What induces Treg cells to express Il23r remains largely unknown. ( 11 ) Given that pro-inflammatory mediators such as IL-6 are involved in the polarization of naïve T cells towards IL-17 producing Th17 cells, which also upregulate Il23r for Th17 cell maintenance ( 12 ), we hypothesized that chronic inflammation may increase Il23r expression in colonic Treg cells. To experimentally test this, Il23r flox/+ Foxp3 YFP-iCre mice were subjected to three cycles of dextran sulfate sodium (DSS) for 5 days that were interrupted by a 10-day rest period each cycle to mimic the relapsing and remitting inflammation experienced by patients with IBD ( Figures 1A, B ).…”
Section: Resultsmentioning
confidence: 99%