Interleukin-27: Biological Properties and Clinical Application

Abstract

Interleukin (IL)-27 is a novel cytokine secreted by stimulated antigen-presenting cells. Initial studies on the biology of IL-27 provided evidence for its role in the initiation of T(H)1 responses; however, subsequent work has indicated that IL-27 has broad inhibitory effects on T(H)1, T(H)2, and T(H)17 subsets of T cells as well as the expansion of inducible regulatory T cells. The involvement of IL-27 in the regulation of angiogenesis and antiviral response has also recently been reported. The aim of this review is to highlight the potential areas of IL-27 clinical application, especially the management of neoplastic and viral diseases as well as autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. The review will also serve to elaborate on the molecular mechanisms involved in the expression of this cytokine and signaling from the IL-27 receptor.

Innate Immune Response of Human Alveolar Macrophages during Influenza A Infection

“…PR/8 also upregulated expression of IL-6 (36.9-fold at 4 hpi and 66.6-fold at 24 hpi), another important cytokine responsible for homeostasis, and several cytokines that activate and regulate adaptive immune response, especially IL-15 and its receptor, IL-23A, and IL-27 [26]–[28] (Data S1). …”

Inflammatory pathway network-based drug repositioning and molecular phenomics

“…In our previous works, the pathway of LPS-induced PGE2 production was constructed 13,14 according to literatures [17][18][19][20][21][22][23][24] . In the same way, the sub-pathways of TNF-α [25][26][27][28] , NO 29-32 , IL-1β 33 , IL-6 34-36 , IL-10 37-39 , IL-12 40-48 , IL-17A 49-52 , IL-23 52-57 , IL-27 58 and IFN-γ 59-62 were also constructed. The visualization of the pathway of inflammation was achieved by using Cytoscape 63 and the network parameters of nodes were calculated by the Network Analysis plugin.…”

Molecular Factors of Cytokine-Dependent Activation of T Cells in Pulmonary Tuberculosis

“…High density of WSX-1 expression on the surface of T cells is assumed to be related to activation of regulatory T cells under the effect of IL-27 and their secretion of IL-10 immunosuppressor cytokine [8,[12][13][14]. Excess of IL-10, in turn, in complex with IL-27 inhibits Th1 cells, including their expression of gp130 receptor molecule, which fact seems to explain low level of gp130 + T cells after in vitro IL-12/IL-27 induction in our study [8,10,15]. Defi cit of gp130 together with WSX-1 hyperexpression on the surface of T cells can tell on the formation of a full-value (functionally) receptor, which leads to inhibition of inducing signals from IL-27.…”

“…The effect of IL-12 on T cells is determined by expression on their surface of the inducible β 2 subunit of IL-12 receptor (IL-12Rβ 2 ), not expressed by silent T cells [4,6,7]. The expression of IL-12Rβ 2 receptor molecule is regulated by T-bet transcription factor, its activity, in turn, depending on the inductive effect of 10,15]. One of subunits of IL-27 receptor is T cell cytokine receptor (WSX-1, TCCR), a type 1 cytokine receptor expressed by naïve CD4 + and CD8 + T cells.…”