Interleukin-29: Just an extra string in the bow of Th17 cells or a target for therapeutic exploitation?

Johnston, Andrew

doi:10.1007/s00109-016-1412-5

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…Strong elevation of antiviral proteins (MX1, BST2, ISG15 and OAS2) in psoriatic lesions correlated with increased level of serum IL-29 and this was explained by IL-29 production by TH17, one of the major players in psoriasis [14]. This may explain the difference in frequency of viral infections in psoriasis (7%) compared to atopic dermatitis (30%) where IL-29 is absent due to decreased level of TH17 and the ability of IL-4 to decrease the IL-29 production.…”

Section: Discussionmentioning

confidence: 93%

Serum level of Interleukin 29 in verruca vulgaris: Case control study

lotfi

Abdelraheem

El-Tahlawi

et al. 2019

Fayoum University Medical Journal

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Verruca vulgaris is a common cutaneous viral infection. It presents as hyperkeratotic, exophytic, dome-shaped papules or nodules often located on fingers, hands, knees, elbows, or sites of trauma. It is common in childern, young adults, and immunosuppressed individuals. IL-29 (also known as IFN-lamda-1) has antiviral activities. IL-29 induces antiviral proteins such as MX1, BST2, ISG15, and OAS2 that increase the antiviral competence of keratinocytes. The aim of this study is to detect the serum level of IL29 in patients infected with verruca vulgaris. This may suggest a possible role of IL29 in HPV infection. This study was in the period between October 2017 and February 2018. Forty patients with verruca vulgaris and forty healthy controls were included. Our results show Serum level of IL-29 was higher in patients than in controls and this was statistically significant (P value = 0.001) Increase serum IL-29 level in patients with verruca vulgaris as a result of chronic infection with HPV and occurs as a defense mechanism against this infection.

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Section: Discussionmentioning

confidence: 93%