Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

He, Peng-yi; Wu, Meng-yao; Zheng, Li-yu; Duan, Yu; Fan, Qi; Zhu, Xiao-mei; Yao, Yong-ming

doi:10.1016/j.cytogfr.2023.12.001

Cytokine & Growth Factor Reviews

2024

DOI: 10.1016/j.cytogfr.2023.12.001

|View full text |Cite

Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

Peng-yi He,

Meng-yao Wu,

Li-yu Zheng

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery

Zhang,

Yue,

Cao

et al. 2024

Acta Biomaterialia

View full text Add to dashboard Cite

Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery

Zhang,

Yue,

Cao

et al. 2024

Acta Biomaterialia

View full text Add to dashboard Cite

Exogenous IL-33 promotes tumor immunity via macroscopic regulation of ILC2s

Feng,

Kuang,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Interleukin-33 (IL-33) is a pleiotropic molecule that plays various roles in the body. However, how exogenous IL-33 changes the tumor immune microenvironment remains unclear. Our study revealed that exogenous IL-33 exerts anti-tumor effects and effectively suppresses the progression of subcutaneous melanoma. scRNA-seq analysis revealed that exogenous IL-33 reduced neutrophils accumulation, thereby improving the inhibitory immune environment. Flow cytometry analysis revealed that exogenous IL-33 significantly increased the proportion of eosinophils and group 2 innate lymphoid cells (ILC2s). In addition, we identified genes encoding major histocompatibility complex (MHC) class II molecules in this group of ILC2s, suggesting that ILC2s may play a role in antigen presentation. In Il7r Cre Arg1 flox/flox mice, the decrease of ILC2s led to a reduction in the proportion of eosinophils. Furthermore, we found that exogenous IL-33 effectively promoted the differentiation of ILC2s and their accumulation in tumors, thereby enhancing the anti-tumor immune response. These findings may pave the way for developing new cancer immunotherapies that use IL-33 as an activator to enhance anti-tumor immune responses. Supplementary Information The online version contains supplementary material available at 10.1038/s41598-024-77751-6.

show abstract

The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren’s syndrome

Dong,

Wang,

2024

Front. Immunol.

View full text Add to dashboard Cite

In the pathogenesis and progression of Sjögren’s syndrome (SS), hematopoietic cells in the peripheral circulation, tissue-resident immune cells, and parenchymal cells of salivary gland tissues (such as epithelial cells, endothelial cells, fibroblasts, etc.) all play crucial roles. These diverse cells form intricate networks and interact with each other, leading to tissue destruction and persistent chronic inflammation, ultimately causing irreversible damage in glandular function. Among these, salivary gland epithelial cells (SGECs) consistently hold a key position, characterized by their functions in expressing co-stimulatory and antigen-presenting molecules and secreting pro-inflammatory cytokines and chemokines. Moreover, SGECs actively engage in and facilitate the development of specific pathological structures within the salivary gland, such as lymphoepithelial lesions (LELs) and tertiary lymphoid structures (TLSs), thereby substantially elevating the risk of mucosa-associated lymphoid tissue (MALT) lymphoma. Overall, SGECs are recognized for their essential and irreplaceable contributions to the pathogenesis of SS. This review article initially delves into the anatomical composition of salivary gland epithelial cells, subsequently focusing on elucidating the different cytokines derived from SGECs, encompassing chemokines, pro-inflammatory cytokines, anti-inflammatory cytokines, pro-survival cytokines, and damage-associated molecular patterns (DAMPs), to explore their key roles in the pathogenesis of SS.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Interleukin-33/serum stimulation-2 pathway: Regulatory mechanisms and emerging implications in immune and inflammatory diseases

Cited by 5 publications

References 116 publications

Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery

Tumor microenvironment-responsive macrophage-mediated immunotherapeutic drug delivery

Exogenous IL-33 promotes tumor immunity via macroscopic regulation of ILC2s

The role of cytokines from salivary gland epithelial cells in the immunopathology of Sjögren’s syndrome

Contact Info

Product

Resources

About