Interleukin-33/ST2 Axis as Potential Biomarker and Therapeutic Target in Kawasaki Disease

Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease

“…We hypothesize that - although ST2 can be expressed by T cells - in MIS-C soluble ST2 is released mostly by the vasculature, 49 , 50 as suggested by the increased levels in KD patients as well. 51 , 52 Both proteins hold promise as future predictive biomarkers for cardiac manifestations in these two diseases.…”