2022
DOI: 10.3748/wjg.v28.i47.6752
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Interleukin-34 deficiency aggravates development of colitis and colitis-associated cancer in mice

Abstract: BACKGROUND Although expression of interleukin (IL)-34 is upregulated in active ulcerative colitis (UC), the molecular function and underlying mechanism are largely unclear. AIM To investigate the function of IL-34 in acute colitis, in a wound healing model and in colitis-associated cancer in IL-34-deficient mice. METHODS Colitis was induced by administration of dextran sodium sulfate (DSS), and carcinogenesis was induced by azoxymethane (AOM)… Show more

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