Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats

Abduh, Maisa Siddiq; Saghir, Sultan Ayesh Mohammed; Al-Gabri, Naif Ahmed; Ahmeda, Ahmad Faheem; Abdelkarim, Mouaadh; Aldaqal, Saleh Mohammad; Alshawsh, Mohammed Abdullah

doi:10.1016/j.sjbs.2023.103806

Cited by 1 publication

(1 citation statement)

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“…Current research has clearly shown that oxidative stress and inflammatory responses jointly participate in the occurrence and development of hepatotoxic injury [ 26 , 27 ]. Oxidative stress is a state of imbalance between oxidation and antioxidants in vivo.…”

Section: Discussionmentioning

confidence: 99%

Arecoline-Induced Hepatotoxicity in Rats: Screening of Abnormal Metabolic Markers and Potential Mechanisms

Sun,

Zhang,

Yin

et al. 2023

Toxics

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Arecoline is a pyridine alkaloid derived from areca nut in the Arecaceae family. It has extensive medicinal activity, such as analgesic, anti-inflammatory, and anti-allergic. However, the toxicity of Arecoline limits its application. Most current studies on its toxicity mainly focus on immunotoxicity, carcinogenesis, and cancer promotion. However, there are few systematic studies on its hepatotoxicity and mechanisms. Therefore, this research explored the mechanism of hepatotoxicity induced by Arecoline in rats and analyzed endogenous metabolite changes in rat plasma by combining network toxicology with metabolomics. The differential metabolites after Arecoline exposure, such as D-Lysine, N4-Acetylaminobutanal, and L-Arginine, were obtained by metabolomics study, and these differential metabolites were involved in the regulation of lipid metabolism, amino acid metabolism, and vitamin metabolism. Based on the strategy of network toxicology, Arecoline can affect the HIF-1 signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, and other concerning pathways by regulating critical targets, such as ALB, CASP3, EGFR, and MMP9. Integration of metabolomics and network toxicology results were further analyzed, and it was concluded that Arecoline may induce hepatotoxicity by mediating oxidative stress, inflammatory response, energy and lipid metabolism, and cell apoptosis.

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Section: Discussionmentioning

confidence: 99%