2024
DOI: 10.21203/rs.3.rs-4030216/v1
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Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features

Nathalie Bendriss-Vermare,
Valentin Picant,
Lara Revol-Bauz
et al.

Abstract: Natural Killer (NK) cells lose their effector functions towards dangerous cells in chronic inflammatory diseases through still elusive mechanisms. Here, we demonstrate that Interleukin 35 (IL-35), an immunosuppressive member of the IL-12 family, inhibits human NK cell proliferation, pro-inflammatory, and cytotoxic functions, while promoting their secretion of TGF-β and proangiogenic factors. Furthermore, prolonged exposure to IL-35 converts NK cells into ILC1-like cells with tissue residency features (CD9+CD10… Show more

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