1994
DOI: 10.1165/ajrcmb.10.5.8179909
|View full text |Cite
|
Sign up to set email alerts
|

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

Abstract: Asthma is characterized by the presence of an inflammatory cell infiltrate in the bronchial mucosa consisting of activated mast cells, eosinophils, and T cells. Several cytokines are considered to play a pivotal role in this response, particularly interleukin (IL)-4, IL-5, IL-6, and tumor necrosis factor-alpha (TNF-alpha). In this study, we have used immunohistochemistry applied to thin glycol methacrylate sections of bronchial mucosal biopsies to define the cellular provenance of these cytokines in normal and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

24
505
2
12

Year Published

1997
1997
2017
2017

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 791 publications
(543 citation statements)
references
References 50 publications
24
505
2
12
Order By: Relevance
“…Even though we find pronounced production of IL-5 in bone marrow cells, it is clear that IL-5 is produced in several tissue compartments, including the lungs (43)(44)(45)(46). Also, in these experiments, we were able to detect increased levels of IL-5 in both BAL fluid and serum after repeated allergen exposure.…”
Section: Discussionmentioning
confidence: 87%
“…Even though we find pronounced production of IL-5 in bone marrow cells, it is clear that IL-5 is produced in several tissue compartments, including the lungs (43)(44)(45)(46). Also, in these experiments, we were able to detect increased levels of IL-5 in both BAL fluid and serum after repeated allergen exposure.…”
Section: Discussionmentioning
confidence: 87%
“…Changes in Th17 cells correlate with asthma induction, making it important to analyze Th-17 proteins such as TNF-α, IL-6, and IL-1β [40]. We previously reported a correlation between TNF-α gene expression [41] and protein levels [42] and the induction of asthma. TNF-α has a chemoattractant effect on neutrophils and eosinophils [17].…”
Section: Discussionmentioning
confidence: 99%
“…With the use of KO mice and adoptive transfer experiments, mast cell-derived TNF-␣ has been shown to contribute significantly to leukocyte infiltration (36). Also, unlike macrophages and lymphocytes, which contain little or no preformed TNF-␣, this cytokine is stored in human mast cells in many tissue sites (5,6,37). But is this TNF-␣ available for rapid release following mast cell activation?…”
Section: Discussionmentioning
confidence: 99%
“…4). Preformed immunoreactive TNF-␣ has been observed within the granules of mast cells from human skin (5) and lung (6), suggesting its rapid availability following mast cell activation. That this preformed TNF-␣ may be biologically relevant has been shown by its release within 2 min of allergen challenge in parallel with tryptase in patients with allergic rhinitis (7).…”
mentioning
confidence: 99%