Interleukin‐4 Gene Polymorphism is not Involved in the Risk of Recurrent Pregnancy Loss

Saijo, Yasuaki; Sata, Fumihiro; Yamada, Hideto; Konodo, Tomoko; Kato, Emi H.; Kataoka, Soromon; Shimada, Shigeki; Morikawa, Mamoru; Minakami, Hisanori; Kishi, Reiko

doi:10.1111/j.1600-0897.2004.00193.x

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…The observed frequency of allele 1 in this study was significantly lower compared to European Caucasians (0.21 vs. 0.79-0.84) (Huang et al 1998;Genevay et al 2002;Hegab et al 2004). The frequency of allele 1 was similar to the frequency reported for a Japanese population (0.26-0.32) (Saijo et al 2004;Hegab et al 2004). Allele 1 with three repeats in the IL-4 VNTR, which is a common allele in Caucasians, was rare in Asians (0.21-0.32).…”

Section: Frequencies Of Genotypessupporting

confidence: 80%

Polymorphisms of RANTES and IL-4 Genes in Cerebral Infarction

Kim

2008

J Mol Neurosci

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Chemoattractant peptides (chemokines) and cytokines have been shown to play a key role in the inflammatory development and progression of cerebrovascular disease. The effect of polymorphisms in regulated upon activation, normal T cells expressed, and secreted (RANTES) and interleukin-4 (IL-4) genes on cerebral infarction (CI) is evaluated in this study. Patients with CI (n = 320) and healthy controls (n = 481) were genotyped for RANTES-403 and IL-4 variable number of tandem repeat (VNTR) polymorphisms using polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism. A significant difference was observed between the CI group and controls in subjects with the RANTES AA genotype in IL-4 A3- carriers (18.6% vs. 13.1%, P = 0.035, odds ratio = 1.5, 95% confidence interval = 1.03-2.25). These findings suggest that the RANTES G-403A allele increased the relative risk for CI in the subjects without the IL-4 VNTR allele 3.

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Section: Frequencies Of Genotypessupporting

confidence: 80%

Polymorphisms of RANTES and IL-4 Genes in Cerebral Infarction

Kim

2008

J Mol Neurosci

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“…Sixteen studies were excluded for the following reasons: five studies were excluded because they were reviews; four studies were excluded for different study objectives; seven studies were excluded because they focused on protein levels; and three studies were excluded because they lacked genotyping data (Fig 1). Ultimately, 31 studies were included (Table 1): 30 articles were used for the meta-analysis, and one article only applied to the literature review because it was the only report of these interleukins[8, 10, 18]. Seven articles assessed IL-1β and included -511C/T, +3593C/T, -1903C/T, -31C/T and -5887C/T[1, 4, 19–23]; twelve articles evaluated IL-6 gene promoter polymorphisms, including -174G/C, -634C/G, -572G/C, -597G/A, -1363G/T, and -2954G/C[3, 5, 14, 24–32]; eleven articles assessed IL-10 gene promoter polymorphisms, including -1082G/A, -592C/A, -819T/C, and -536A/G[3, 14, 23, 24, 30, 31, 33–37]; and five articles evaluated IL-18 gene promoter polymorphisms and included -137G/C, -607C/A, -119A/C, -105G/A, and -656C/A[9, 38–41].…”

Section: Resultsmentioning

confidence: 99%

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Zhang

Bao

et al. 2017

PLoS ONE

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Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0.62,0.96]), IL-6 (-634C/G) (P<0.001, 95% CI 2.91[2.01,4.22]), IL-10 (-1082G/A, –819T/C) (P = 0.01, 95% CI 0.80[0.67,0.96]; P<0.01, 95% CI 0.66[0.49,0.89]), and IL-18 (-137G/C, -105G/A) (P<0.01, 95% CI 1.69[1.24,2.31]; P = <0.01, 95% CI 1.41[1.17,1.70]) consistently associated with RPL after meta-analysis. IL-17A rs2275913 and IL-17F rs763780, IL-21 rs2055979 and rs13143866, IL-1β (-31C/T), IL-6 (-2954G/C), and IL-10 (-536A/G) were reported only once as having a significant association with RPL. The potential mechanism underlying miscarriage and these polymorphisms and future research directions are also discussed.

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“…In spite of many reports concerning the Th1/Th2 system during pregnancy showing elevated levels of IL‐4 and its relation to undisturbed pregnancy, there are arguments that IL‐4 does not play as important a role as it appears at first glance. It was shown, for example, that polymorphism of the IL‐4 gene has no connection to the risk of pregnancy loss and foetal antigen tolerance (Bonney 2001; Saijo et al. 2004).…”

Section: The Janus Kinase/signal Transducers and Activators Of Transcmentioning

confidence: 99%

Pleiotropy and Redundancy of STAT Proteins in Early Pregnancy

Maj

Chełmońska-Soyta

2007

Reprod Domestic Animals

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Signal transducers and activators of transcription (STATs) are a group of proteins involved in signal transduction from numerous bioactive substances. Hormones and cytokines such as leukaemia inhibitory factor, interferon-tau and prolactin, which play key roles during early pregnancy, activate the Janus kinase (JAK)/STAT signalling pathway. The STATs are thus involved in the regulation of implantation, establishing uterine receptivity and regulation of the maternal immune response. It seems that STATs can orchestrate signals from hormones and cytokines in different cell types and may therefore generate numerous biological effects, despite the relatively small number of receptors activating the JAK/STAT pathway. This review summarizes the participation of STATs in the main processes of early pregnancy, especially regarding their pleiotropy and redundancy.

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Interleukin‐4 Gene Polymorphism is not Involved in the Risk of Recurrent Pregnancy Loss

Abstract: The present study suggests that the IL-4 VNTR allele is not a major genetic regulator in RPL.

Cited by 16 publications

References 22 publications

Polymorphisms of RANTES and IL-4 Genes in Cerebral Infarction

Polymorphisms of RANTES and IL-4 Genes in Cerebral Infarction

Association between Genetic Polymorphisms in Interleukin Genes and Recurrent Pregnancy Loss – A Systematic Review and Meta-Analysis

Pleiotropy and Redundancy of STAT Proteins in Early Pregnancy

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