Interleukin-6 (174G/C) Gene Polymorphism and Serum Levels of IL-6, their Association with Risk of Obesity in Iraqi Childhood Populations

Abstract

Background: Childhood obesity is one of the most serious public health challenges of the 21st century. Aim:The present study was conducted to investigate the association of CD14 genotype and serum levels of IL-6 with risk of ischemic stroke.Method : A total of 60 patients with obesity were included in the study who were admitted to hospital from the period between March to August 2020, and other groups consist of 60 apparently healthy individuals. A five ml of blood samples were collected, 3 ml of each sample for polymerase chain reaction amplification and detection of IL-6 technique. The remaining (2 ml) for IL-6 serum levels by ELISA assay procedure.Results: IL-6 (-174G/C) genotype was significantly associated with increased risk of obesity (P = 0.004). However, IL-6 serum levels were higher in subjects with GG genotype compared with those with CG or CC genotype (P < 0.001). Conclusion:A significant correlation between IL-6 genotype and IL-6 levels were higher level in subjects with GG genotype compared with those with CG or CC genotype.