1990
DOI: 10.1016/1043-4666(90)90069-6
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Interleukin 6 and expression of its receptor on epidermal keratinocytes

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Cited by 78 publications
(44 citation statements)
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“…While knowledge about the differentiation and proliferation of epidermal keratinocytes is expanding rapidly, there are only sparse reports about the functional capacity of keratinocytes derived from mucosa [26]. Nearly all functional studies on keratinocytes are carried out with subcultivated cells [12,18,27]. Subcultivation usually means the adherence of cells, confluency and various times of culture.…”
Section: Introductionmentioning
confidence: 99%
“…While knowledge about the differentiation and proliferation of epidermal keratinocytes is expanding rapidly, there are only sparse reports about the functional capacity of keratinocytes derived from mucosa [26]. Nearly all functional studies on keratinocytes are carried out with subcultivated cells [12,18,27]. Subcultivation usually means the adherence of cells, confluency and various times of culture.…”
Section: Introductionmentioning
confidence: 99%
“…Several chemokines and cytokines, including IL-6 and IL-8, are expressed in both primary and immortalized vaginal and cervical epithelial cells, aiding in both innate and adaptive immunity (6, 9 -13). In the cervix, IL-6 gene expression can be induced by pathogen infection (14,15) and exposure to pro-inflammatory cytokines such as TNF␣ (16,17). IL-6 activates T-cells, causing them to differentiate, and also plays a role in cervical dilation and tumor angiogenesis (18,19).…”
mentioning
confidence: 99%
“…Leukocytosis and fever have been found to be the result of increased production of IL-6 in vivo (16). In addition, IL-6 can induce the proliferation of mesangial cells (17), epidermal keratinocytes (18), and various tumor cells such as malignant lymphomacells, multiple myelomacells, and renal carcinoma cells (6), as well as the differentiation of osteoclasts (19). From a study using IL-6 transgenic mice, we have been able to learn what kinds of abnormalities the hyperproduction ofIL-6 can cause in vivo.…”
Section: Introductionmentioning
confidence: 99%