Interleukin 6 and Interleukin 1β hypomethylation and overexpression are common features of apical periodontitis: A case-control study with gingival tissue as control

Adeodato, Caroline Sousa Ribeiro; Soares-Lima, Sheila Coelho; Batista, Paula Vieira; Fagundes, Marina Chianello Nicolau; Camuzi, Diego; Tavares, Sandro Junio Oliveira; Pinto, Luís Felipe Ribeiro; Scelza, Míriam Zaccaro

doi:10.1016/j.archoralbio.2023.105694

Cited by 2 publications

(1 citation statement)

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“…In line with this statement, the IL6 promoter was hypomethylated in PD cases compared to controls. Importantly, elevated gene expression of IL6 was detected in patients with apical PD, and similar findings were observed in the case of IL1β [98]. Furthermore, a study by Zhang et al focused on PTGS2 promoter methylation, comparing periodontally inflamed gingiva vs. non-inflamed gingiva.…”

Section: Dna Methylationmentioning

confidence: 53%

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

Ustianowska,

Ustianowski,

Bakinowska

et al. 2024

Cells

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Periodontitis (PD) is a prevalent and chronic inflammatory disease with a complex pathogenesis, and it is associated with the presence of specific pathogens, such as Porphyromonas gingivalis. Dysbiosis and dysregulated immune responses ultimately lead to chronic inflammation as well as tooth and alveolar bone loss. Multiple studies have demonstrated that genetic polymorphisms may increase the susceptibility to PD. Furthermore, gene expression is modulated by various epigenetic mechanisms, such as DNA methylation, histone modifications, or the activity of non-coding RNA. These processes can also be induced by PD-associated pathogens. In this review, we try to summarize the genetic processes that are implicated in the pathogenesis of PD. Furthermore, we discuss the use of these mechanisms in diagnosis and therapeutic purposes. Importantly, novel treatment methods that could promote tissue regeneration are greatly needed in PD. In this paper, we also demonstrate current evidence on the potential use of stem cells and extracellular vesicles to stimulate tissue regeneration and suppress inflammation. The understanding of the molecular mechanisms involved in the pathogenesis of PD, as well as the impact of PD-associated bacteria and stem cells in these processes, may enhance future research and ultimately improve long-term treatment outcomes.

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Section: Dna Methylationmentioning

confidence: 53%