Interleukin-6 and the Risk of Future Cardiovascular Events in Patients With Angina Pectoris and/or Healed Myocardial Infarction

Fisman, Enrique Z.; Benderly, Michal; Esper, Ricardo J.; Behar, Solomon; Boyko, Valentina; Adler, Yehuda; Tanné, David; Matas, Zipora; Tenenbaum, Alexander

doi:10.1016/j.amjcard.2006.01.045

Cited by 151 publications

(125 citation statements)

References 20 publications

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“…In the last few years, mechanisms related to immune system involvement in atherosclerosis have become more clear [66,67]. Proinflammatory markers C-reactive protein (CRP) and interleukin-6 have been shown to indicate worse prognosis in adults with unstable angina and myocardial infarction [68][69][70]. More data on markers including adiponectin, Eselectin and soluble IL-2 receptor in diabetic individuals have become available from clinical research studies associating these markers with clinical and subclinical coronary disease [71][72][73].…”

Section: Inflammationmentioning

confidence: 97%

Cardiovascular disease risk in youth with diabetes mellitus

Wadwa

2006

Rev Endocr Metab Disord

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In the United States, cardiovascular disease is the leading cause of mortality in adults with diabetes over age 30 years. Studies in persons without diabetes have shown that atherosclerosis, a central factor in cardiovascular disease, begins in childhood and the presence of cardiovascular disease risk factors in youth lead to increased cardiovascular disease risk in adults. Therefore, youth with diabetes are at increased risk for developing cardiovascular disease as adults and there is a role for risk factor screening and addressing modifiable factors to lower cardiovascular disease risk starting in childhood. This paper reviews the literature on traditional cardiovascular disease risk factors in youth with diabetes including hyperglycemia, hypertension, dyslipidemia, smoking, obesity and family history of cardiovascular disease with an emphasis on type 1 diabetes as well as current American Diabetes Association guidelines for screening and treatment of modifiable risk factors. Current roles of inflammatory markers and measures of subclinical vascular changes such as arterial stiffness are also discussed.

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Section: Inflammationmentioning

confidence: 97%

Cardiovascular disease risk in youth with diabetes mellitus

Wadwa

2006

Rev Endocr Metab Disord

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“…Furthermore, serum levels of upstream activators of STAT3, in particular the interleukin IL-6 cytokines, such as leukemia inhibitory factor (LIF), and cardiotrophin (CT)-1 are elevated in patients with cardiac insufficiency and serve as a strong independent predictor for the morbidity and mortality in patients with chronic heart failure after myocardial infarction [132][133][134]. Additionally, serum levels of the soluble form of the gp130 receptor (sgp130), the common receptor subunit of all IL-6 cytokines, appear to correlate with the severity of left ventricular dysfunction in addition to already established prognostic markers such as B-type natriuretic peptides [135,136].…”

Section: Stat3 and Anthracycline-induced Cardiotoxicitymentioning

confidence: 99%

STAT3 and cardiac remodeling

et al. 2010

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Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 interacts with a broad range of cellular and molecular mechanisms that direct remodeling processes in cardiac physiology (exercise, pregnancy) and pathophysiology (pressure overload, ischemia/reperfusion, myocardial infarction, and cardiotoxic agents). STAT3 is constitutively activated by a multitude of factors including cytokines, growth factors, neurohormones, mechanical load, and ischemia. It acts as a signaling molecule, a transcription factor and according to latest observations as a mitochondrial protein involved in energy production. In this review, we provide an overview on STAT3 signaling and summarize the current understanding of the role of STAT3 for different aspects of cardiac remodeling obtained from numerous experimental and clinical studies. Finally, we highlight and critically discuss STAT3 signaling as a possible target for future therapeutic approaches in the setting of cardiac remodeling.

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“…Proinflammatory cytokines also appear to be elevated following episodes of myocardial ischemia [126] and unstable angina [127]. Cytokine profiles may also predict risk for cardiac events [128,129].…”

Section: Cytokines and Heart Diseasementioning

confidence: 99%

Psychobiology of depression/distress in congestive heart failure

2008

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Heart failure affects millions of Americans and new diagnosis rates are expected to almost triple over the next 30 years as our population ages. Affective disorders including clinical depression and anxiety are common in patients with congestive heart failure. Furthermore, the presence of these disorders significantly impacts quality of life, medical outcomes, and healthcare service utilization. In recent years, the literature has attempted to describe potential pathophysiologic mechanisms relating affective disorders and psychosocial stress to heart failure. Several potential mechanisms have been proposed including autonomic nervous system dysfunction, inflammation, cardiac arrhythmias, and altered platelet function. These mechanisms are reviewed in this article. Additional novel mechanisms such as mental stress-induced myocardial ischemia are also discussed.

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Interleukin-6 and the Risk of Future Cardiovascular Events in Patients With Angina Pectoris and/or Healed Myocardial Infarction

Cited by 151 publications

References 20 publications

Cardiovascular disease risk in youth with diabetes mellitus

Cardiovascular disease risk in youth with diabetes mellitus

STAT3 and cardiac remodeling

Psychobiology of depression/distress in congestive heart failure

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