Interleukin-6 concentrations in neonatal sepsis

Önal, Esra; Kitapci, Füsun; Dilmen, U; Adam, Bahattin

doi:10.1016/s0140-6736(05)77250-0

Cited by 24 publications

(16 citation statements)

References 3 publications

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“…Several acute-phase reactants such as C-reactive protein (CRP) and interleukin-6 (IL-6) have proven helpful in the diagnosis of an ongoing infection. However, the rate at which each marker begins to show elevations and the time to normalization differs with each marker (3)(4)(5)(6)(7).…”

mentioning

confidence: 99%

Proadrenomedullin as a prognostic marker in neonatal sepsis

et al. 2012

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confidence: 99%

Proadrenomedullin as a prognostic marker in neonatal sepsis

et al. 2012

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“…25 The explanation for the significant relationship between high IL-6 levels and reduced survival is unclear. Although IL-6 levels are elevated in patients with inflammatory disorders including sepsis, 7 all of our patients were free of clinical sepsis on day 0 when the sample for IL-6 analysis was taken, and only three died within 30 days of the transplant. The relationship we found was, in fact, between IL-6 levels on day 0 and overall survival, including survival beyond the immediate transplant period.…”

Section: Discussionmentioning

confidence: 73%

“…6 It may be increased in infections 7 and in patients with Hodgkin's disease (HD). 8 High serum levels correlate with adverse features and poor survival in patients with newly diagnosed low-grade non-Hodgkin's lymphoma (NHL).…”

mentioning

confidence: 99%

Association between high interleukin-6 levels and adverse outcome after autologous haemopoietic stem cell transplantation

Tegg

Griffiths

Lowenthal

et al. 2001

Bone Marrow Transplant

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Summary:We studied interleukin-6 (IL-6) levels on the day of transplantation in 31 patients undergoing autologous haemopoietic stem cell transplantation (SCT) (either peripheral blood stem cell transplantation (PBSCT) or bone marrow transplantation (BMT)) for neoplastic diseases to determine if there was a relationship between IL-6 level and rate of haemopoietic recovery, length of stay in hospital, and survival. There was no apparent delay in post-transplant recovery associated with elevated IL-6 levels. However, increased values of IL-6 tended to be associated with an increased length of stay in hospital (P = 0.083). There was a highly significant adverse association between higher IL-6 levels and survival following transplantation (P = 0.0001). This association remained significant (P = 0.013) in the uniform subgroup of patients with malignant lymphoma with chemosensitive disease who had undergone BMT (that is, excluding patients who had undergone PBSCT) (n = 13). Knowledge of IL-6 levels on the day of transplant has the potential to provide valuable prognostic information in patients undergoing autologous haemopoietic SCT. Bone Marrow Transplantation (2001) 28, 929-933.

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“…It is synthesized and released rapidly (reaching its peak level in 3 h) in response to inflammatory stimuli, preceding the increase in CRP. Several studies have demonstrated the diagnostic value of elevated IL-6 blood levels in preterm and term neonates with infection [7,16,[23][24][25]. Being the major inducer of CRP synthesis in the liver, IL-6 is a potentially useful diagnostic marker of earlyonset septicemia, but reports are conflicting, quoting sensitivities of 69-100% and specificities of 36-93% [26].…”

Section: Cytokinesmentioning

confidence: 99%

Immunologic markers in the neonatal period: diagnostic value and accuracy in infection

Kafetzis¹,

Tigani²,

Costalos

2005

Expert Review of Molecular Diagnostics

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Diagnosis of early-onset neonatal infection has led to the development of several screening tests including C-reactive protein, a very commonly used marker, and cytokines (mainly interleukin-6 and -8), alone or in combination with C-reactive protein, based on the premise that their increases in response to infection may precede that of C-reactive protein. In recent years the search for diagnostic tests has turned to procalcitonin, a propeptide of calcitonin, which appears to be a promising marker of infection in newborn infants. Additionally, specific leukocyte cell surface antigens (mainly CD11b and CD64), detected by flow cytometry, are evaluated as markers of neonatal infection, since their expression on the cell membrane increases in substantial quantities after leukocyte activation by bacteria or their cellular products. This review aims to examine the role of these newly available immunologic indices and to assess their validity as diagnostic markers of infection during the neonatal period.

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Interleukin-6 concentrations in neonatal sepsis

Cited by 24 publications

References 3 publications

Proadrenomedullin as a prognostic marker in neonatal sepsis

Proadrenomedullin as a prognostic marker in neonatal sepsis

Association between high interleukin-6 levels and adverse outcome after autologous haemopoietic stem cell transplantation

Immunologic markers in the neonatal period: diagnostic value and accuracy in infection

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