Interleukin‐6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without Cyclosporine A–Induced Gingival Overgrowth

Gürkan, Ali; Becerik, Sema; Öztürk, Veli Özgen; Atmaca, Harika; Atilla, Gül; Emingil, Gülnur

doi:10.1902/jop.2015.150003

Cited by 7 publications

(14 citation statements)

References 56 publications

(141 reference statements)

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“…Table 1 lists the characteristics of the included studies. Four case-control studies were included from the United States [63,64], Poland [32], and Turkey [65]. The study sample sizes ranged from 40 [65] to 162 participants [64].…”

Section: Study Selectionmentioning

confidence: 99%

“…Four case-control studies were included from the United States [63,64], Poland [32], and Turkey [65]. The study sample sizes ranged from 40 [65] to 162 participants [64]. Globally, this review comprised a total of 420 participants (237 males and 183 females), 274 transplant recipients (167 males and 107 females), and 146 healthy controls (70 males and 76 females).…”

Section: Study Selectionmentioning

confidence: 99%

“…Data from four studies [32,[63][64][65], including 420 patients reported IL-6 serum and GCF levels of transplanted and healthy patients. All 274 transplant recipients were heart and kidney transplanted patients.…”

Section: Il-6 Levels Of Transplanted Patients Vs Healthy Patientsmentioning

confidence: 99%

“…Diagnostics 2020, 10, x; doi: FOR PEER REVIEW www.mdpi.com/journal/diagnostics Table 2 (NOS Scale scores) shows the risk of bias assessment for the included studies. All four studies were considered of low risk of bias and, therefore, of high quality [32,[63][64][65]. Specifically, one study described an alternative periodontal case definition [64].…”

Section: Il-6 Levels Of Transplanted Patients Vs Healthy Patientsmentioning

confidence: 99%

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Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

et al. 2020

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This systematic review aimed to investigate the influence of periodontitis on post-transplant IL-6 serum levels of solid organ transplanted patients as compared to healthy subjects. Four databases (PubMed, Scholar, EMBASE, and CENTRAL) were searched up to February 2020 (PROSPERO CRD42018107817). Case-control and cohort studies on the association of IL-6 serum levels with a periodontal status of patients after solid organ transplantation were included. The risk of bias of observational studies was assessed through the Newcastle-Ottawa Scale (NOS). Random effects meta-analyses were thoroughly conducted. GRADE assessment provided quality evidence. Four case-control studies fulfilled the inclusion criteria (274 transplant recipients and 146 healthy controls), all of low risk of bias. Meta-analyses revealed significantly higher IL-6 levels in transplanted patients than healthy individuals with low-quality evidence (Mean Difference (MD): 2.55 (95% confidence interval (CI): 2.07, 3.03)). Transplanted patients with periodontitis have higher serum IL-6 levels than transplanted patients without periodontitis with moderate quality evidence (MD: 2.20 (95% CI: 1.00, 3.39)). We found low-quality evidence of higher IL-6 levels than healthy patients in patients with heart and kidney transplant. In these transplanted patients, there was moderate quality evidence that periodontitis is associated with higher IL-6 serum levels. Future research should consider the impact of such a difference in organ failure and systemic complications.

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Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Il-6 Levels Of Transplanted Patients Vs Healthy Patientsmentioning

confidence: 99%

Section: Il-6 Levels Of Transplanted Patients Vs Healthy Patientsmentioning

confidence: 99%

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Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

et al. 2020

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“…Gingival enlargement was assessed using hyperplastic index (HI) (18). This index has been used frequently in recent studies (19,20). After examination, the periodontal health status of the subjects was evaluated using a biofilm-gingival interface (BGI) classification system (21).…”

Section: Periodontal Evaluationmentioning

confidence: 99%

Gingival enlargement in children with sickle cell disease

2018

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The purpose of the present study was to evaluate periodontal health status in children with sickle cell disease (SCD). Forty-nine children with SCD and 39 systemically healthy sex- and age-matched children were enrolled in the study. Plaque index, gingival index, bleeding on probing, pocket depth, salivary volume, and hyperplastic index were recorded. In addition, the histopathological evaluation of gingiva was made in a child with SCD. There were significant differences between the groups with regard to hyperplastic index (P < 0.05), whereas there were no differences in other parameters. Gingival enlargement was detected in 27 children (55.1%) in the SCD group and 6 children (15.4%) in the control group (P < 0.001). However, there were no differences in periodontal health status of children in the SCD and control groups, the most important finding of this study that the gingival enlargement was more prevalent in children with SCD. Sickling and chronic inflammation seen in SCD may affect gingival tissues. Therefore, physicians and dentists must be aware of the effects of SCD on gingival tissues.

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Cyclosporine A – Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis

Ricardo

Prado

Carvalho

et al. 2019

Journal of Oral Biology and Craniofacial Research

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The most important microscopic characteristic of Cyclosporine A-induced gingival overgrowth is fibroepithelial hyperplasia. Objective: The objective was to investigate the influence of previous exposure to Cyclosporine A over gingival epithelium in experimental periodontitis in rats. Methods: Twenty Wistar rats with 12 weeks-old were divided into four groups with 5 animals each: Control Group (CG); Cyclosporine Group (CsAG); Ligature group (LG) and Cyclosporine and Ligature Group (CsALG). Daily doses of CsA (10 mg/kg) were applied to CsAG and CsALG during 60 days since the beginning of the experiment and, a ligature was placed in LG and CsALG 30 days after the beginning of the experiment. After 60 days, animals were euthanized and gingival tissue was processed to histomorphometric analysis of epithelial thickness (mm 2), immunohistochemical expression of PCNA (%) and inflammatory response. Data were analyzed by Kruskal-Wallis and Mann Whitney at 0.05 significance level. Results: Considering epithelial thickness, CG was thinner than all groups, CsALG was the largest and CsAG and LG were similar between each other. Regarding the PCNA expression CG (16.46 ± 9.26) was similar to CsAG (34.47 ± 19.75) and, LG (59.02 ± 10.33) was similar to CsALG (40.59 ± 18.25). Significant difference (p < 0.05) occurred only in inflammation presence comparing CG/LG and CsAG/CsALG. A weak positive correlation between the number of PCNA+ and inflammatory cells (p = 0.001; r = 0.611) was observed. Conclusion: Based on these results it was concluded that the enlargement of gingival epithelium observed in experimental periodontitis can be increased by previous exposition to CsA and inflammatory conditions enhanced proliferative activity of the keratinocytes.

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Interleukin‐6 Family of Cytokines in Crevicular Fluid of Renal Transplant Recipients With and Without Cyclosporine A–Induced Gingival Overgrowth

Cited by 7 publications

References 56 publications

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

Periodontitis Impact in Interleukin-6 Serum Levels in Solid Organ Transplanted Patients: A Systematic Review and Meta-Analysis

Gingival enlargement in children with sickle cell disease

Cyclosporine A – Induced gingival overgrowth and proliferating cell nuclear antigen expression in experimental periodontitis

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