2015
DOI: 10.1002/14651858.cd011811
|View full text |Cite
|
Sign up to set email alerts
|

Interleukin-6 for diagnosis of sepsis in critically ill adult patients

Abstract: This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:To determine the diagnostic accuracy of interleukin-6 (IL-6) for the diagnosis of bacterial sepsis in critically ill adult patients.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
10
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 16 publications
(10 citation statements)
references
References 48 publications
0
10
0
Order By: Relevance
“…There are three peaks observed in the anodic scan (E (a 1 ) = 0.16 V, E (a 2 ) = 0.45 V, and E (a 3 ) 0.77 V vs. Ag) and four in the cathodic scan (E (c 1 ) = 0.66 V, E (c 2 ) = 0.55 V, E (c 3 ) = 0.42 V, E (c 4 ) = 0.02 V vs. Ag). At the beginning of the electropolymerisation, the CV is performed on the pure Au-SPE, causing Au oxidation (E = 1 V) and reduction (E = 0.51 V) [ 57 , 58 ]. The monomer aniline oxidation, which is the first step in the aniline electropolymerisation occurs at E = 0.9 V [ 43 ] in the anodic scan.…”
Section: Resultsmentioning
confidence: 99%
“…There are three peaks observed in the anodic scan (E (a 1 ) = 0.16 V, E (a 2 ) = 0.45 V, and E (a 3 ) 0.77 V vs. Ag) and four in the cathodic scan (E (c 1 ) = 0.66 V, E (c 2 ) = 0.55 V, E (c 3 ) = 0.42 V, E (c 4 ) = 0.02 V vs. Ag). At the beginning of the electropolymerisation, the CV is performed on the pure Au-SPE, causing Au oxidation (E = 1 V) and reduction (E = 0.51 V) [ 57 , 58 ]. The monomer aniline oxidation, which is the first step in the aniline electropolymerisation occurs at E = 0.9 V [ 43 ] in the anodic scan.…”
Section: Resultsmentioning
confidence: 99%
“…IL-6 is a predictor of mortality in COVID-19 patients [43]. However, in severely affected patients, IL-6 is moderately increased (25.2 pg/mL) [36] compared to typical levels in cytokine release syndromes (more than 1600 pg/mL in sepsis) [29]. This may explain why no serious vasoplegic shocks were observed.…”
Section: Notch and The "Cytokine Storm"mentioning
confidence: 97%
“…Conventional diagnosis of sepsis relies on recognition of infection, which can be challenging in comatose patients. Positive microbiological cultures (which can take days) remains the gold standard for diagnosis, along with key clinical assessments including temperature, white cell count (WCC), C-reactive protein (CRP), and blood lactate [9, 10]. Significant developments in the field of sepsis diagnosis attempt to address the lengthy time required to perform blood cultures.…”
Section: Introductionmentioning
confidence: 99%
“…Although these new methods enable more rapid diagnosis, current limitations include high cost (£140–£160/test) and specialised laboratory equipment requirements [11]. Bedside detection of raised IL-6 levels in the blood would aid the diagnosis of infection, thereby enabling the fast and effective treatment necessary to combat this disease [8, 10, 12].…”
Section: Introductionmentioning
confidence: 99%