Interleukin 6 in neonates with early and late onset infection

Panero, Alessandra; Pacifico, Lucia; Rossi, Naila; Mancuso, Giovanna; Stegagno, M; Chiesa, Claudio

doi:10.1097/00006454-199704000-00007

Cited by 92 publications

(109 citation statements)

References 19 publications

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“…The possibility that earlier diagnosis of sepsis might also improve infant outcome is attractive. Several other markers have been studied in these patients and some seem to be promising (29,(37)(38)(39)(40)(41). The results in the present study suggest that daily CD11b expression measurements might prove useful in the earlier diagnosis of late-onset infection in ELBW infants, but larger multi-center trials with sufficient number of patients are needed to explore potential utility of such markers.…”

Section: Discussionmentioning

confidence: 78%

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Turunen¹,

Andersson²,

Nupponen³

et al. 2005

Pediatr Res

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Section: Discussionmentioning

confidence: 78%

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Turunen¹,

Andersson²,

Nupponen³

et al. 2005

Pediatr Res

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“…Others have assigned infants with only maternal risk factor(s) for infection to the sepsis group "to develop criteria that are relevant and simple enough for clinical practice" (40 ). In other studies, the presence of two or three categories (by organ system) of clinical signs of infection in the infant has been taken to strongly support a diagnosis of septicemia (41)(42)(43). Absent from neonatology publications, however, are data on just how common a given clinical sign is in all infants ever evaluated (rather than in infants with positive cultures or infants with a specific type of infection).…”

Section: Systemic Response To Infection In Newbornsmentioning

confidence: 99%

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge

et al. 2004

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“…[5][6][7][8][9] Neither very premature infants or those whose mothers had been exposed to prenatal corticosteroids were included in the study. Ex-vivo sepsis study has shown a decreased IL-6 presence in monocytes of those infants in comparison to term and near-term newborns, and adults.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown sensitivity in the range of 75 to 90% in the first 24 hours of neonatal infection, and an abrupt decrease 48 hours after the beginning of clinical manifestations. [6][7][8][9] Recent studies reported high IL-6 levels in umbilical cord blood in newborns with early-onset sepsis whose mothers had chorioamnionitis. 10,11 However, even though some newborn infants presented neonatal infection, they had low plasma IL-6 levels.…”

Section: Introductionmentioning

confidence: 99%

A influência do tempo de coleta sobre os níveis de interleucina-6 na sepse neonatal precoce

Procianoy¹,

Silveira²

2004

J. Pediatr. (Rio J.)

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Objective: To assess different perinatal findings and sample collection timing in newborns with early-onset sepsis comparing those with low IL-6 levels to the ones with high levels.Methods: Eighty-five newborn infants, with clinical signs of sepsis and/or positive blood cultures, had plasma IL-6 collected in the initial evaluation for early-onset sepsis in the first 96 hours of life. They were classified in two groups according to their plasma IL-6 levels: higher, and equal to or lower than IL-6 median value for the whole septic groupResults: Median IL-6 for the whole group was 89 pg/ml. High and low level groups were formed by 42 and 43 newborns respectively. There were no differences between the two groups regarding gestational ages, birth weights, cesarean-section proportion, Apgar scores, number of neonates with maternal risk factors for infection, number of maternal intrapartum antibiotic therapy, and number of positive blood cultures. Median plasma IL-6 in the high level group was 287 pg/ml, and in the low level group 46 pg/ml (p < 0.001). Median sample timing was 17.5 hours of life for the high level group and 36 hours of life for the low level group (p < 0.001). There was a significant negative correlation coefficient between IL-6 levels and sample collection timing. Conclusion:Sample collection timing is an important factor for detection of high plasma IL-6 level in newborn infants with earlyonset sepsis. ResumoObjetivo: Avaliar os diferentes achados perinatais e o tempo da coleta da amostra em recém-nascidos com sepse neonatal precoce, comparando os recém-nascidos com nível baixo e alto de IL-6.Métodos: Oitenta e cinco recém-nascidos com sinais clínicos de sepse e/ou hemoculturas positivas tiveram plasma coletado na avaliação inicial da sepse neonatal precoce nas primeiras 96 horas de vida. Foram divididos em: a) acima (grupo de nível elevado) e b) igual ou abaixo (grupo de nível baixo) da mediana da IL-6 do grupo total.Resultados: A mediana da IL-6 para o grupo total foi de 89 pg/ml. Os grupos de nível elevado e de nível baixo foram constituídos por 42 e 43 recém-nascidos, respectivamente. Não houve diferença significativa entre ambos os grupos quanto a idade gestacional, peso de nascimento, proporção de parto cesariano, escores de Apgar, número de recém-nascidos cujas mães tiveram fator de risco para infecção, número de mães que receberam antibiótico intraparto e número de hemoculturas positivas. A mediana da IL-6 plasmática do grupo de nível elevado foi 287 pg/ml, e do grupo de nível baixo foi 46 pg/ml (p < 0,001). A mediana do tempo de coleta foi 17,5 horas de vida no grupo de nível elevado e 36 horas de vida no grupo de nível baixo (p < 0,001). Houve uma significante correlação negativa entre níveis de IL-6 e tempo de coleta da amostra.Conclusão: O tempo de coleta da amostra é um fator importante para a detecção de níveis elevados de IL-6 em recém-nascidos com sepse neonatal precoce. The role of sample collection timing on interleukin-6 levels in early-onset neonatal sepsis A influência d...

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Interleukin 6 in neonates with early and late onset infection

Cited by 92 publications

References 19 publications

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Increased CD11b-Density on Circulating Phagocytes as an Early Sign of Late-Onset Sepsis in Extremely Low-Birth-Weight Infants

Diagnosis of Neonatal Sepsis: A Clinical and Laboratory Challenge

A influência do tempo de coleta sobre os níveis de interleucina-6 na sepse neonatal precoce

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