Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction

Alogna, Alessio; Koepp, Katlyn E.; Sabbah, Michael; Espindola Netto, Jair M.; Jensen, Michael D.; Kirkland, James L.; Lam, Carolyn S.P.; Obokata, Masaru; Petrie, Mark C.; Ridker, Paul M.; Sorimachi, Hidemi; Tchkonia, Tamara; Voors, Adriaan; Redfield, Margaret M.; Borlaug, Barry A.

doi:10.1016/j.jchf.2023.06.031

Cited by 23 publications

(7 citation statements)

References 42 publications

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“…Chia et al [21] studied the risk of onset of HF in the general population, and they found that IL-6 levels were significantly correlated with the onset of HFpEF but not HFrEF. Similar results were also found by Alogna et al [23], although their study was not based on the general population but on patients with HFpEF. They found, in particular, that IL-6 was related to more severe symptoms and a higher BMI.…”

Section: Interleukin-6supporting

confidence: 88%

“…BNP and NT-proBNP are the two natriuretic peptides with the most diagnostic value for heart failure [72]. The significant correlation that emerged between IL-6 and HF-pEF [22,23] could be an input to continue investigating whether IL-6 constitutes a potential parameter for monitoring HF and a possible therapeutic target. Indeed, the correlation of IL-6 and Nt-proBNP levels with 30-day but not 180-day mortality [22] identifies IL-6 as a possible marker to monitor to identify patients at high risk of rehospitalization.…”

Section: Discussionmentioning

confidence: 99%

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A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Pagano,

Corallo,

D’Aleo

et al. 2024

Biomolecules

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Background: Heart failure is an epidemiologically relevant disease because of the aging population and widespread lifestyles that promote it. In addition to the acute event, it is possible for the disease to become chronic with periodic flare-ups. It is essential to study pathology from a diagnostic and prognostic point of view and to identify parameters for effective monitoring. In addition, heart failure is associated with multiple comorbidities, including cognitive impairment, which is monitored clinically but not through specific biomarkers in these patients. The purpose of this review is to gather the most recent scientific evidence on a few possible biomarkers previously identified for monitoring heart failure and associated cognitive impairment. Methods: We surveyed studies inherent to a set of previously identified markers, evaluating English-language articles from the past five years conducted in adult heart failure patient populations. We used the databases PubMed, Web of Sciences, and Cochrane Library for search studies, and we considered articles published in journals with an impact factor greater than five in the publication year. Results: Among the biomarkers evaluated, a concordant indication for serial measurements for heart failure monitoring emerged only for interleukin-6. For the other markers, there is still little evidence available, which is interesting but sometimes conflicting. Interesting studies have also emerged for biomarkers of cognitive decline assessed in patients with heart failure, confirming the hypotheses of the increasingly studied heart-brain correlation. Conclusion: Certainly, further studies in large populations are needed to identify effective biomarkers for monitoring heart failure and associated cognitive impairment.

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Section: Interleukin-6supporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Pagano,

Corallo,

D’Aleo

et al. 2024

Biomolecules

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“…Individuals with elevated IL-6 levels have a higher risk of heart failure compared to those without a history of cardiovascular disease. 27 IL-17 enhanced the release of pro-inflammatory cytokines including IL-1 and IL-6. 28 , 29 Patients with higher levels of IL-17 were more likely to have atrial fibrillation (AF), kidney dysfunction and heart failure with preserved ejection fraction (HFpEF).…”

Section: Discussionmentioning

confidence: 97%

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Zhao,

Qi,

Zhang

et al. 2024

JIR

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The aim of this study was to explore the relationship between inflammatory cytokines and the risk of heart failure (HF) readmission in patients with heart failure with preserved ejection fraction (HFpEF). Patients and Methods: We enrolled 429 patients with HFpEF admitted to the cardiology department in our hospital from January 2020 to July 2022. The patients were divided into the readmission or non-readmission groups according to whether they were readmitted for heart failure within 1 year of discharge. The clinical features and laboratory date of the subjects were collected and analyzed. Multivariate cox regression analysis was used to identify predictors of HF readmission. In addition, receiver operating characteristic (ROC) curves were used to determine the prognostic value of each factor. Results: The levels of IL-1β, IL-6, IL-10, IL-17, TNF-α, NT-proBNP, heart rate, total cholesterol and NYHA class were significantly higher in the readmission group than in the non-readmission group (p < 0.05). IL-1β, IL-6, IL-17, TNF-α, NT-proBNP, heart rate and NYHA class were identified as independent predictors of HF readmission. Conclusion: Inflammatory markers, including IL-1β, IL-6, IL-17 and TNF-α were related to the HF readmission in patients with HFpEF.

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“…A recent report described enhanced IL-6 levels in patients with HF and preserved LVEF; IL-6 was associated with higher BMI, total fat mass, trunk fat mass, as well as with raised serum NT-proBNP, CRP and TNF-α levels; furthermore, it was associated with worse renal function, lower haemoglobin levels, and impaired glucose metabolism [ 39 ]. Despite our evaluation of patients with intermediate or reduced LVEF, in our study, IL-6 was positively correlated with BMI, fat mass and CRP, and even after nutritional intervention, it still correlated with RF-AT.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Support Reduces Circulating Cytokines in Patients with Heart Failure

Herrera-Martínez,

Jiménez,

Romo

et al. 2024

Nutrients

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Increased inflammation is associated with the pathogenesis of heart failure (HF). Increased circulating levels of cytokines have been previously reported and generally associated with worse clinical outcomes. In this context, the modulation of inflammation-related parameters seems to be a reasonable therapeutic option for improving the clinical course of the disease. Based on this, we aimed to compare changes in circulating cytokines when Mediterranean diet alone or in combination with hypercaloric, hyperproteic oral nutritional supplements (ONS), enriched with omega−3 (n−3) polyunsaturated fatty acids were administered to patients with HF. Briefly, patients were randomly assigned to receive Mediterranean Diet (control group) vs. Mediterranean Diet plus ONS (intervention group). We observed increased circulating levels of IL-6, IL-8, MCP-1 and IP-10. MCP-1 and IL-6 were associated with overweight and obesity (p = 0.01–0.01–0.04, respectively); IL-6 and IL-8 were positively correlated with fat mass and CRP serum levels (p = 0.02–0.04, respectively). Circulating levels of IL-8 significantly decreased in all patients treated with the Mediterranean diet, while IL-6 and IP-10 only significantly decreased in patients that received plus ONS. In the univariate analysis, MCP-1 and its combination with IL-6 were associated with increased mortality (p = 0.02), while the multivariate analysis confirmed that MCP-1 was an independent factor for mortality (OR 1.01, 95%ci 1.01–1.02). In conclusion, nutritional support using hypercaloric, hyperproteic, n-3 enriched ONS in combination with Mediterranean Diet was associated with decreased circulating levels of some cytokines and could represent an interesting step for improving heart functionality of patients with HF.

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Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction

Cited by 23 publications

References 42 publications

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

A Set of Possible Markers for Monitoring Heart Failure and Cognitive Impairment Associated: A Review of Literature from the Past 5 Years

Prognostic Value of Inflammatory Cytokines in Predicting Hospital Readmissions in Heart Failure with Preserved Ejection Fraction

Nutritional Support Reduces Circulating Cytokines in Patients with Heart Failure

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