Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice

Kuroyanagi, Gen; Kamiya, Nobuhiro; Yamaguchi, Ryosuke; Kim, Harry K.W.

doi:10.1016/j.ocarto.2023.100386

Osteoarthritis and Cartilage Open

2023

DOI: 10.1016/j.ocarto.2023.100386

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Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice

Gen Kuroyanagi¹,

Nobuhiro Kamiya²,

Ryosuke Yamaguchi³

et al.

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2024

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Cited by 1 publication

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Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro

Shimasaki,

Ueda,

Sakurai

et al. 2024

Biomolecules

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Inflammation and oxidative stress are crucial for osteoarthritis (OA) pathogenesis. Despite the potential of pharmacological pretreatment of chondrocytes in preventing OA, its efficacy in preventing the progression of cartilage damage and promoting its recovery has not been examined. In this study, an H2O2-induced human OA-like chondrocyte cell model was created using H1467 primary human chondrocytes to evaluate the efficacy of interleukin (IL)-6 and cyclooxygenase (COX)-2 inhibitors (tocilizumab and celecoxib, respectively) in the prevention and treatment of cartilage damage. H2O2 significantly elevated the IL-6, COX-2, and matrix metalloproteinase (MMP)-13 levels. Although monotherapy decreased the levels, nuclear shrinkage and altered cell morphology, similar to those in the H2O2 group, were observed. The expression of these factors was significantly lower in the combination therapy group, and the cell morphology was maintained. Moreover, the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was activated, and levels of the antioxidant protein heme oxygenase-1 (HO-1) were increased, especially in the combination group, indicating an anti-inflammatory effect. The treatment groups, particularly the combination group, demonstrated increased cell viability. Overall, the drug combination exhibited superior efficacy in preventing the progression of cartilage damage and promoted its recovery compared with the monotherapy. Given that the drugs herein are already in clinical use, they are suitable candidates for OA treatment.

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Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro

Shimasaki,

Ueda,

Sakurai

et al. 2024

Biomolecules

View full text Add to dashboard Cite

show abstract

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Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice

Cited by 1 publication

References 51 publications

Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro

Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro

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