Interleukin‐6 receptor rs2229238C/T and rs4845625T/C polymorphisms increase the risk of schizophrenia in an Iranian population: A pilot study

Abstract

Objective Interleukin-6 (IL-6) is an important cytokine that plays a key role in the immune system. Changes in the immune system, particularly increased IL-6 concentrations, have been reported in schizophrenia (SCZ) patients. Although this cytokine needs its receptor (IL-6R) to function properly, few studies have examined IL-6R polymorphisms and the risk of SCZ. The aim of the present study was to evaluate the possible association between IL-6R polymorphisms (rs2229238 and rs4845625) and susceptibility to SCZ. Methods A case-control study was carried out including 92 SCZ patients and 92 healthy controls. Two single-nucleotide polymorphisms were genotyped using amplification-refractory mutation system polymerase chain reaction. Results It was found that the TC genotype of rs4845625 and CT and TT of rs2229238 increased the SCZ risk (OR 2.691, 95% CI 1.075-6.736, P = 0.034; OR 4.273, 95% CI 1.937-9.433, P < 0.001; and OR 2.123, 95% CI 1.071-4.219, P = 0.031, respectively). In dominant genetic model analysis, it was found that CT+TT of rs2229238 and TC+CC of rs4845625 were associated with the risk of SCZ (OR 2.762, 95% CI 1.426-5.376, P = 0.003 and OR 2.824, 95% CI 1.545-5.154, P < 0.001, respectively). Conclusions The findings showed that the rs2229238 and rs4845625 singlenucleotide polymorphisms were prominently associated with SCZ. Further studies are required to confirm the findings.

Melatonin Receptor 1B Gene Polymorphisms, Haplotypes and Susceptibility to Schizophrenia

“…Although the etiology of SCZ is entirely unknown, there is much evidence Original research article DOI: 10.1515DOI: 10. /rrlm-2017 that genetic factors play important roles in pathogenesis and the development of SCZ (1)(2)(3)(4)(5).…”