Interleukin-7 and interleukin-15 as prognostic biomarkers in sepsis and septic shock: Correlation with inflammatory markers and mortality

Leśnik, Patrycja; Janc, Jarosław; Mierzchala-Pasierb, Magdalena; Tański, Wojciech; Wierciński, Jan; Łysenko, Lidia

doi:10.1016/j.cyto.2023.156277

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Moreover, innovative approaches to augment IL-7 in immunosuppressed septic shock patients have been shown to enhance T lymphocyte functions ex vivo, including increased production of IFN-γ and TNF-α ( 36 ). The ability of IL-7 to promote T cell viability, trafficking, and functionality aligns with observed improvements in survival rates among sepsis patients ( 37 ). This apparent contradiction, wherein CD127-mediated pathways contribute to the progression of sepsis while IL-7 supplementation shows therapeutic benefits, may be explained by considering the temporal dynamics of sepsis.…”

Section: Discussionmentioning

confidence: 58%

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits

Liu,

Wang,

Zhao

et al. 2024

Front. Immunol.

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BackgroundAcute pancreatitis (AP) is a severe digestive system disorder with a significant risk of progressing to sepsis, a major cause of mortality. Unraveling the immunological pathways in AP is essential for developing effective treatments, particularly understanding the role of specific immune cell traits in this progression.MethodsEmploying a bidirectional two-sample Mendelian Randomization (MR) approach, this study first examined the causal relationship between AP and 731 immune cell traits to identify those significantly associated with AP. Subsequently, we explored the causal associations between 731 immune cell traits and sepsis. The analysis utilized extensive genome-wide association studies (GWAS) summary datasets, with a focus on identifying common immune cell traits with statistically significant causal associations between AP and sepsis.ResultsOur investigation identified 44 immune cell traits unidirectionally associated with AP and 36 traits unidirectionally associated with sepsis. Among these, CD127 on CD28+ CD45RA- CD8+ T cells emerged as a common mediator, accounting for 5.296% of the increased risk of sepsis in AP patients. This finding highlights the significant role of specific memory CD8+ T cells in the pathophysiology of AP and its progression to sepsis.ConclusionThis study elucidates the critical role of specific immune cell traits, particularly CD127hi memory CD8+ T cells, in the progression of AP to sepsis. Our findings provide a foundation for future research into targeted immune-modulatory therapies, potentially improving patient outcomes in AP-related sepsis and offering new insights into the complex immunological dynamics of this condition.

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Section: Discussionmentioning

confidence: 58%

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits

Liu,

Wang,

Zhao

et al. 2024

Front. Immunol.

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“…The immunopathogenesis of disease progression in elderly patients with sepsis is characterized by broad immune cell apoptosis, profound immune exhaustion, amplified immunosuppressive effects of Tregs, deranged inflammaging, and dysfunction of immunometabolism, including mitochondrial metabolism. Remarkably, previous studies have shown that IL-7 administration can reverse sepsis-induced lymphopenia by inhibiting apoptosis and improving the proliferation of T lymphocytes, which was recently demonstrated in a clinical trial [ 29 , 30 ]. In addition, IL-7 increases the activation and promotes the rejuvenation of T cells in patients with immunosenescence, as reported by Marton et al [ 31 ].…”

Section: Discussionmentioning

confidence: 97%

Single-cell landscape of immunological responses in elderly patients with sepsis

He,

Yao,

Wang

et al. 2024

Immun Ageing

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Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a special population influenced by immunosenescence, are more susceptible to sepsis and have a worse prognosis. However, the immunopathogenic mechanisms underlying sepsis in elderly patients remain unclear. Here, we performed single-cell RNA sequencing of peripheral blood samples from young and old subjects and patients with sepsis. By exploring the transcriptional profiles of immune cells, we analyzed immune cell compositions, phenotype shifts, expression heterogeneities, and intercellular communication. In elderly patients with sepsis, innate immune cells (e.g., monocytes and DCs) exhibit decreased antigen presentation, presenting an overactive inflammatory and senescent phenotype. However, the immunophenotype of T cells shifted to characterize effector, memory, and exhaustion. Moreover, we identified strong interferon-γ responses of T cells in both aging and sepsis groups and a deranged inflammaging status in elderly sepsis patients. Tregs in elderly patients with sepsis showed increased abundance and enhanced immunosuppressive effects. In addition, metabolism-associated pathways were upregulated in T cells in elderly patients with sepsis, and the lysine metabolism pathway was enriched in Tregs. Cell–cell interaction analysis showed that the expression profile of ligand-receptor pairs was probably associated with aggravated immune dysfunction in elderly patients with sepsis. A novel HLA-KIR interaction was observed between Tregs and CD8 + T cells. These findings illustrate the immunological hallmarks of sepsis in elderly patients, and highlight that immunosuppressive and metabolic regulatory pathways may undergo important alterations in elderly patients with sepsis.

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“…In a study of patients followed up in the ICU with a diagnosis of sepsis and septic shock, [ 33 ] it was shown that SOFA had no significant effect on mortality. However, this result was not comparable to the fact that SOFA predicted mortality in patients with septic shock in the current study.…”

Section: Discussionmentioning

confidence: 99%

The role of proadrenomedullin, interleukin 6 and CD64 in the diagnosis and prognosis of septic shock

Turan

2023

BMC Anesthesiol

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Introduction Sepsis and septic shock are disorders of tissue perfusion and microcirculation associated with increased mortality. The role of biomarkers such as proadrenomedullin (PRO-ADM), interleukin 6 (IL-6) and neutrophil CD64 (CD64) in the diagnosis and prognosis of septic shock has been studied. Methods GCS, SOFA score, APACHE 2 score, lactate, CRP, procalcitonin, PRO-ADM, IL-6, CD64 level and 28-day mortality were evaluated in patients with septic shock followed-up in the intensive care unit of Marmara University Hospital between July 2021 and December 2021. The study was planned as prospective, non-drug clinical research Committee. Results There were no statistically significant differences between patient groups in gender, BMI, and presence of comorbidities (p > 0.05). The alive patient group had significantly higher GCS values and lower SOFA, APACHE 2, lactate and CD64 values than the dead patient group (p < 0.01). The cut-off values of laboratory parameters were determined using ROC analysis to predict mortality, SOFA and CD64 had high AUC. This is also a good indicator for mortality.The multivariate logistic regression model was estimated using the backward selection method. The mortality of ICU patients was predicted by a SOFA-value ≥ 12 (OR (95%CI) = 56.13 (5.44–578.64)), CD64 value ≥ 28.54 (OR (95% CI) = 23.78 (2.61–216.85)), and ADM-value ≥ 86.79 (OR (95% CI) = 15.86 (1.02–246.49)) (p < 0.05) . Conclusion In conclusion, serum CD64 level, PRO-ADM level, and SOFA score proved to be effective parameters for predicting prognosis and mortality in septic shock. However, IL-6 proved to be a weak biomarker and failed to predict mortality. CD64, which is easier and more practical to use, can be used instead of the SOFA score.

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Interleukin-7 and interleukin-15 as prognostic biomarkers in sepsis and septic shock: Correlation with inflammatory markers and mortality

Cited by 7 publications

References 35 publications

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits

Single-cell landscape of immunological responses in elderly patients with sepsis

The role of proadrenomedullin, interleukin 6 and CD64 in the diagnosis and prognosis of septic shock

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