Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes – Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features

Hoffmann, Maximilian; Enczmann, Jürgen; Balz, Vera; Kummer, Sebastian; Reinauer, Christina; Döing, Carsten; Förtsch, Katharina; Welters, Alena; Vasconcelos, Malte Kohns; Mayatepek, Ertan; Meißner, Thomas; Jacobsen, Marc; Seyfarth, Julia

doi:10.1016/j.clim.2022.108928

Cited by 5 publications

(6 citation statements)

References 39 publications

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“…In the literature, rs6897932 polymorphism of the IL7R gene was found to be associated with susceptibility to multiple autoimmune diseases [30]. The protective effect of the T allele in rs6897932 SNP was first shown in multiple sclerosis (MS) and other autoimmune diseases including T1D [15,31,32]. Observations on the association of the protective effect of the T allele in other autoimmune diseases remain consistent with our results in patients with autoimmune thyroid diseases.…”

Section: Il7rsupporting

confidence: 90%

“…The cytokine IL7 and its receptor, IL7R, are essential for T and B cell development, as well as the differentiation and survival of naive T cells and the generation and maintenance of memory T cells [10,11]. Stimulation of the receptor for Interleukin 7 (IL7R) has been shown to play an important role in the development and progression of autoimmune diseases [12][13][14][15]. The IL7R gene has been identified as one of the key genes and pathways associated with the development of Hashimoto's thyroiditis [16].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases

Borysewicz-Sańczyk,

Wawrusiewicz-Kurylonek,

Gościk

et al. 2024

IJMS

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Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are common autoimmune endocrine disorders in children. Studies indicate that apart from environmental factors, genetic background significantly contributes to the development of these diseases. This study aimed to assess the prevalence of selected single-nucleotide polymorphisms (SNPs) of Il7R, CD226, CAPSL, and CLEC16A genes in children with autoimmune thyroid diseases. We analyzed SNPs at the locus rs3194051, rs6897932 of IL7R, rs763361 of CD226, rs1010601 of CAPSL, and rs725613 of CLEC16A gene in 56 HT patients, 124 GD patients, and 156 healthy children. We observed significant differences in alleles IL7R (rs6897932) between HT males and the control group (C > T, p = 0.028) and between all GD patients and healthy children (C > T, p = 0.035) as well as GD females and controls (C > T, p = 0.018). Moreover, the C/T genotype was less frequent in GD patients at rs6897932 locus and in HT males at rs1010601 locus. The presence of the T allele in the IL7R (rs6897932) locus appears to have a protective effect against HT in males and GD in all children. Similarly, the presence of the T allele in the CAPSL locus (rs1010601) seems to reduce the risk of HT development in all patients.

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Section: Il7rsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases

Borysewicz-Sańczyk,

Wawrusiewicz-Kurylonek,

Gościk

et al. 2024

IJMS

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“…SNPs for IL-7 in T1DM patients were investigated in several valuable works [14,20,31,32]. Hoffman M. et al [14] revealed higher sIL-7R serum concentrations at T1DM onset and decreasing levels during therapy, whereas IL-7 was only higher in long-term patients compared to controls. Hehenkamp P. et al [20] elucidated that T1DM monocytes have an impaired IL-7 response and lower IL-7R expression.…”

Section: Discussionmentioning

confidence: 99%

“…Hoffman M. et al, 2022 [14] There are higher sIL-7R serum concentrations at T1DM onset and decreasing levels during therapy, whereas IL-7 was only higher in long-term patients as compared to controls. Li J. et al, 2022 [15] Increased serum IL-17A is a risk factor for autoimmune T1DM.…”

Section: Conflicts Of Interestmentioning

confidence: 97%

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

D’Agostino,

Valentini,

Dolci

2024

Children

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Diabetes can trigger an increase in cytokine levels leading to the production of C-reactive protein and fibrinogen. These molecules promote subclinical inflammation, causing the expression of adhesive molecules and endothelial dysfunction. Despite the lack of a comprehensive panel for single-nucleotide polymorphisms (SNPs) for interleukins associated with type 1 diabetes mellitus (T1DM), understanding the inflammatory role of SNPs is crucial because periodontitis, the sixth complication of diabetes, is influenced via these genetic variations. This review focuses on the interleukin levels in T1DM patients with and without periodontitis, with a particular focus on childhood and on SNPs when reported. A search of PubMed and Scopus identified 21 relevant studies from the past five years. Several ILs were analyzed, emphasizing that T1DM still needs to be thoroughly explored regarding an IL polymorphisms panel; however, the last five years have led to the increased independence of this condition, causing autonomous inflammatory effects, which require further investigation. The periodontitis and T1DM association in children and adolescents represents a severe gap in the literature that should be filled; this scarce presence of studies serves as motivation for further clinical research.

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“…SNPs for IL-7 in T1DM patients was investigated in several valuable works [13,19,30,31]. Hoffman M. et al [13] revealed a higher sIL-7R serum concentrations at T1DM onset and decreasing levels during therapy, whereas IL-7 was only higher in long term patients as compared to controls. Hehenkamp P. et al [19] elucidated that T1DM monocytes have impaired IL-7 response and lower IL-7R expression.…”

Section: Discussionmentioning

confidence: 99%

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

D’Agostino¹,

Valentini²,

Iarussi³

et al. 2023

Preprint

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Diabetes may cause an increase blood levels of cytokines inducing a rising of C reactive protein (PCR) and fibrinogen stimulating a subclinical inflammation which lead to adhesive molecules expression and to endothelial disfunction. A comprehensive panel of type 1 diabetes mellitus (T1DM) interleukins polymorphisms is not provided yet. As chronic periodontitis (CP) is considered the sixth complication of DM, a clarification is needed about the inflammatory role managed by single nucleotides polymorphisms (SNPs). The goal of this review is to focus on the significant diversity of SNPs in T1DM patients with and without CP. After a digital search on PubMed and Scopus with reference to the last 5 years, 21 items were enrolled. Several ILs were analyzed. T1DM still needs to be thoroughly explored regarding the ILs polymorphisms panel, however the last 5 years have led to the increased independence of this condition, causing autonomous inflammatory effects which requires further investigations. CP and T1DM association in children and adolescents represents a severe gap in literature that should be filled, the scarce presence of studies also about adults serves as a motivation for ulterior clinical researches

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Interleukin-7 and soluble Interleukin-7 receptor levels in type 1 diabetes – Impact of IL7RA polymorphisms, HLA risk genotypes and clinical features

Cited by 5 publications

References 39 publications

Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases

Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases

Exploring Interleukin Levels in Type 1 Diabetes and Periodontitis: A Review with a Focus on Childhood

Interleukins Polymorphisms In Type-1 Diabetes And Perio-dontitis: A Review

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