Interleukin 7 receptor activates PI3K/Akt/mTOR signaling pathway via downregulation of Beclin‐1 in lung cancer

Ming, Jian; Zhu, Yun-Jia; Ding, Zhiying; Yanduo, Jiang; Guocheng, Jiang

doi:10.1002/mc.22933

Cited by 33 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-7 and its receptor IL-7R, are able to induce PI3K/Akt/mTOR signaling pathway via downregulating Beclin1. In parallel, they showed, by in situ analysis of human NSCLC, that overexpression of IL-7/IL-7R and mTOR plays an important role in decreasing lung cancer cell autophagy and increases tumor development [ 134 ].…”

Section: Myokines and Autophagymentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

View full text Add to dashboard Cite

Aging and sedentary life style are considered independent risk factors for many disorders. Under these conditions, accumulation of dysfunctional and damaged cellular proteins and organelles occurs, resulting in a cellular degeneration and cell death. Autophagy is a conserved recycling pathway responsible for the degradation, then turnover of cellular proteins and organelles. This process is a part of the molecular underpinnings by which exercise promotes healthy aging and mitigate age-related pathologies. Irisin is a myokine released during physical activity and acts as a link between muscles and other tissues and organs. Its main beneficial function is the change of subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequential increase in thermogenesis. Irisin modulates metabolic processes, acting on glucose homeostasis, reduces systemic inflammation, maintains the balance between resorption and bone formation, and regulates the functioning of the nervous system. Recently, some of its pleiotropic and favorable properties have been attributed to autophagy induction, posing irisin as an important regulator of autophagy by exercise. This review article proposes to bring together for the first time the “state of the art” knowledge regarding the effects of irisin and autophagy. Furthermore, treatments on relation between exercise/myokines and autophagy have been also achieved.

show abstract

Section: Myokines and Autophagymentioning

confidence: 99%

Irisin and Autophagy: First Update

Pesce

Ballerini

Paolucci

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Recent studies indicated that the expression of Beclin1 and mTOR were well correlated with survival and clinical stages of human non-small cell lung cancer (NSCLC) patients. Indeed, IL-7 activates PI3 K/Akt/mTOR signaling pathway via Beclin1 to regulate autophagy in lung cancer cells (Jian et al, 2019). What is more, it has been reported that Beclin1 was up-regulated in 67.7% of NSCLC patients, and was suggested that high Beclin-1 expression predicts longer survival in locally advanced NSCLC (Lee et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Investigation the Role of Autophagy in Non-Small Cell Lung Cancer

Pargol

Karizi

Akbari

et al. 2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

The last two subtypes, compromises 25-30% and 40% of all NSCLC patients, respectively. The prognosis of lung cancer remains poor and despite various progresses in diagnostic and therapeutic processes, the 5-year survival has only increased from 15.7% to 17.4% during the last decade (Boolell et al., 2015).Macro-autophagy (hereafter referred to as autophagy), which is a homeostatic mechanism regulating degradation of proteins, organelles, and other cellular components in lysosomes, plays an important role in cancer initiation,

show abstract

“…Interleukin-7 (IL-7) has been detailed to the required for both B-cell and T-cell proliferation and its lack would result in immature immune cell arrest. IL-7 can modulate cell growth, as well as apoptosis and modulate cancer lymphangiogenesis [41][42]. Apoptosis is a form of programmed cell death.…”

Section: Discussionmentioning

confidence: 99%

A Genomic-Clinicopathologic Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Gastric Cancer

Zhong

Xuan

Qian

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Preoperative evaluation of the lymph node (LN) state is of pivotal significance for therapy strategy decisions in gastric cancer (GC) patients. However, there is lack of noninvasive method that can identify such status preoperatively. We aimed at developing a genomic biosignature based model to forecast the possibility of LN metastasis in GC patients.Methods: We employed the RNA profile retrieving strategy and conducted RNA expression profiling in a large GC cohort (GSE62254, n = 300) from Gene Expression Ominus (GEO). In the exploratory stage, 300 GC patients from GSE62254 were involved and the differentially expressed RNAs (DERs) for LN-status were determined using R software. The GC samples in GSE62254 were randomly divided into a learning set (n = 210) and a verification set (n = 90). By performing the Least absolute shrinkage and selection operator (LASSO) regression approach, a set of 23-RNA signature was established and the signature based nomogram was subsequently built for distinguishing LN condition. The diagnostic effectiveness of this model was assessed, as well as the clinical performance subsequently assessed using the decision curve analysis (DCA). Metascape was used for bioinformatic analysis of the DERsResults: Based on this genomic signature, we established a nomogram which robustly distinguished LN status in the learning (AUC = 0.916, 95% CI 0.833–0.999) and verification sets (AUC = 0.775, 95% CI 0.647–0.903). DCA demonstrated the clinical value of this nomogram. Functional enrichment analysis of the DERs was conducted using bioinformatics methods which posited that these DERs were involved with several lymphangiogenesis-correlated cascades.Conclusions: Here, we present a genomic signature based nomogram that integrates the 23-RNA biosignature based scores and Lauren classification. This model can be readily utilized to estimate the possibility of LN metastasis with good performance in GC. The uncovering of the DERs reveals the prospective biogenesis of LN metastasis in GC.

show abstract

Interleukin 7 receptor activates PI3K/Akt/mTOR signaling pathway via downregulation of Beclin‐1 in lung cancer

Cited by 33 publications

References 22 publications

Irisin and Autophagy: First Update

Irisin and Autophagy: First Update

Investigation the Role of Autophagy in Non-Small Cell Lung Cancer

A Genomic-Clinicopathologic Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Gastric Cancer

Contact Info

Product

Resources

About