2020
DOI: 10.1101/2020.09.02.280362
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Interleukin 7 receptor (IL7R) is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells

Abstract: Respiratory diseases are a leading cause of death worldwide, with highly varied vulnerability to disease between individuals. The underlying reasons of disease susceptibility are unknown, but often include a variable immune response in lungs. Recently, we identified a surprising novel role of the interleukin 7 receptor (IL7R), a primarily lymphoid-associated regulator, in fetal-specified, lung-resident macrophage development. Here, we report that traditional, hematopoietic stem cell-derived myeloid cells in th… Show more

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Cited by 5 publications
(1 citation statement)
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“…Second, we removed the host cell variable by quantifying the absolute numbers of donor-derived mature cells in the PB of recipient mice (Boyer et al, 2019;Cool et al, 2020;Rajendiran et al, 2020aRajendiran et al, , 2020b to more quantitatively assess the differences in regenerative activity between young and old HSCs. Old HSCs generated fewer erythroid, GM, B, T, and Plt cells compared with young HSCs (Figure 2C); this observation is consistent with host cell production presented as donor-derived chimerism (Figure 2B).…”
Section: Old Hscs Exhibit Impaired Reconstitution Potential Compared With Young Hscsmentioning
confidence: 99%
“…Second, we removed the host cell variable by quantifying the absolute numbers of donor-derived mature cells in the PB of recipient mice (Boyer et al, 2019;Cool et al, 2020;Rajendiran et al, 2020aRajendiran et al, , 2020b to more quantitatively assess the differences in regenerative activity between young and old HSCs. Old HSCs generated fewer erythroid, GM, B, T, and Plt cells compared with young HSCs (Figure 2C); this observation is consistent with host cell production presented as donor-derived chimerism (Figure 2B).…”
Section: Old Hscs Exhibit Impaired Reconstitution Potential Compared With Young Hscsmentioning
confidence: 99%