1993
DOI: 10.1152/ajplung.1993.264.4.l413
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Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases

Abstract: Sputum from patients with cystic fibrosis, bronchiectasis, and chronic bronchitis contains neutrophils and neutrophil proteases, which have been implicated in the pathophysiology of mucus hypersecretion in airways. We asked whether interleukin-8 (IL-8), a potent neutrophil chemoattractant, might be involved in recruiting neutrophils into airways of patients with cystic fibrosis, bronchiectasis, and chronic bronchitis. We found significant neutrophil chemotactic activity in sputum obtained from these patients. … Show more

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Cited by 228 publications
(221 citation statements)
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“…This did not reflect differences in therapy and the exsmokers had worse lung function which would, if anything, increase neutrophil numbers [3,4]. IL-8 is thought to be a major airways neutrophil chemoattractant [30] and is increased in healthy smokers [3] and subjects with COPD [3] although the effect of smoking cessation has not been assessed previously. The current data indicate that cessation of smoking in chronic bronchitis is related to a reduction in airways IL-8 concentration that in turn would reduce neutrophil recruitment, thereby explaining the beneficial effect of smoking cessation on progression of lung disease.…”
Section: Discussionmentioning
confidence: 99%
“…This did not reflect differences in therapy and the exsmokers had worse lung function which would, if anything, increase neutrophil numbers [3,4]. IL-8 is thought to be a major airways neutrophil chemoattractant [30] and is increased in healthy smokers [3] and subjects with COPD [3] although the effect of smoking cessation has not been assessed previously. The current data indicate that cessation of smoking in chronic bronchitis is related to a reduction in airways IL-8 concentration that in turn would reduce neutrophil recruitment, thereby explaining the beneficial effect of smoking cessation on progression of lung disease.…”
Section: Discussionmentioning
confidence: 99%
“…Of particular interest is the strong inhibitory effect of IL-10 on neutrophil expression of IL-8 and TNF- [61,62]. Secretion of IL-8, TNF-and other proinflammatory cytokines by airway epithelial cells and lung macrophages with accumulation and activation of neutrophils in the CF airways may underlie the early pathogenesis of CF lung disease [58,59,63,64]. This inflammatory process is greatly magnified by epithelial cell IL-8 production stimulated by products of colonizing bacterial pathogens and neutrophils [65,66].…”
Section: Discussionmentioning
confidence: 99%
“…It belongs to the alpha-subfamily (C-X-C) of chemokine superfamily [1][2][3][4] and plays an important role in many immune and inflammatory responses. IL-8 has been reported to be present in high concentration in inflammatory exudates of a large number of neutrophil driven acute and chronic inflammatory diseases and upto 98% of neutrophil accumulation can be reduced by the addition ofmAbs of IL-8, suggesting IL-8 to be the principal chemokine responsible for chemoattraction of neutrophils in these diseases [5][6][7].…”
Section: Introductionmentioning
confidence: 99%