Interleukin-8 as a sensitive marker of unstable coronary artery disease

Expression of Matrix Metalloproteinases in Patients With Acute Myocardial Infarction

“…14 On the other hand, production of MMP-1 by PBMCs was significantly elevated after the onset of AMI in the present patients and we also found that production of MMP-1 by PBMCs was related to plasma CRP level after AMI. Levels of several cytokines such as IL-1 , IL-6, IL-8 and tumor necrosis factor (TNF)-have been reported to be elevated in the acute stage of AMI, [21][22][23][24][25][26][27][28] and we have previously reported that plasma IL-6 levels were related to those of CRP. 29 Other studies have clarified that these proinflammatory cytokines regulate MMP-1 expression.…”

Automated quantitation of peripheral blood neutrophil activation in patients with myocardial ischaemia

“…Markers such as C-reactive protein (CRP) [12,11], troponin T, fibrinogen, interleukin (IL) 1, 6 and 8 [13], the adhesion molecule soluble intercellular adhesion molecule-1 (sICAM-1) [14], the integrins CD18 and CD11b on monocytes and neutrophils [15] and homocysteine [16], are all found at increased levels in the serum of patients with significant ischaemia. Many of these mediators correlate with disease severity and prognosis, and may be utilised in risk stratification [17].…”

Loss of Pentameric Symmetry in C-Reactive Protein Induces Interleukin-8 Secretion Through Peroxynitrite Signaling in Human Neutrophils

“…1,2 The C-X-C chemokine interleukin-8 (IL-8) is a sensitive marker of unstable CAD. 3 Increases in IL-8 levels may coincide with increased CRP levels, 4 though IL-8 does not directly stimulate CRP gene expression. 5,6 Increased plasma levels of nitrotyrosine, a "molecular fingerprint" for nitric oxidederived oxidants, 7 are also associated with the presence of CAD.…”