Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins α5 and β1

Jovanović, Milica; Stefanoska, Ivana; Radojčić, Ljiljana; Vićovac, Ljiljana

doi:10.1530/rep-09-0341

Cited by 198 publications

(146 citation statements)

References 43 publications

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“…Depression of the mRNA of this gene in preeclampsia has been confirmed by reverse transcription-polymerase chain reaction in a previous study (Li et al, 2013), which is consistent with our results. In humans, during trophobalst invasion, trophoblast cells acquire variations in the integrin phenotype, acquiring integrins a5b1 and a1b1 (Jovanović et al, 2010). Regulation of normal human trophoblast cell invasion may be important in the mechanisms underlying preeclampsia (Li et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Partial least squares-based gene expression analysis in preeclampsia

Jiang¹,

Yang²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Preeclampsia is major cause of maternal and fetal morbidity and mortality. Currently, the etiology of preeclampsia is unclear. In this study, we investigated differences in gene expression between preeclampsia patients and controls using partial least squaresbased analysis, which is more suitable than routine analysis. Expression profile data were downloaded from the Gene Expression Omnibus database. A total of 503 genes were found to be differentially expressed, including 248 downregulated genes and 255 overexpressed genes. Network analysis identified 5 hub genes, including UBB, PIK3R1, MAPRE1, VEGFA, and ITGB1. Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-6599 PLS analysis in preeclampsia ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6598-6604 (2015) related biological processes. Our findings shed light on expression signatures of preeclampsia patients that can be used as theoretical support in future therapeutic studies.

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Section: Discussionmentioning

confidence: 99%

Partial least squares-based gene expression analysis in preeclampsia

Jiang¹,

Yang²,

Li³

et al. 2015

Genet. Mol. Res.

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“…CXCL10 is expressed in vascular endothelial and vascular smooth muscle cells in the placenta and extravillous trophoblast-induced CXCL10 expression contributes to a reshaping of the spiral arteries by altering the motility and differentiation status of vascular smooth muscle cells in blood vessels (53). CXCL6 has been observed to restrict human trophoblast cell migration and invasion in vitro by suppressing matrix metalloproteinase (MMP)-2 activity in the first trimester of pregnancy (29).…”

Section: Chemokines and Preeclampsiamentioning

confidence: 99%

Association between preeclampsia and the CXC chemokine family (Review)

Liu

Dai

Zhou

2015

Experimental and Therapeutic Medicine

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Abstract. Preeclampsia is a major cause of maternal and perinatal mortality and morbidity, characterized by gestational hypertension, proteinuria, systemic endothelial cell activation and an exaggerated inflammatory response. The precise cause of preeclampsia is not currently known; however, it is widely accepted that the pathogenesis of preeclampsia involves inadequate trophoblast invasion, leading to generalized endothelial dysfunction and an exaggerated inflammatory response. Chemokines are a superfamily of structurally similar proteins that mediate cell recruitment, angiogenesis, immunity and stem cell trafficking. CXC chemokines are a family of cytokines, unique in their ability to behave in a disparate manner in the regulation of angiogenesis. The CXC chemokine family further divides into two subfamilies; CXC ELR+, which promotes angiogenesis, and CXC ELR-, which inhibits angiogenesis. Furthermore, CXC chemokines are involved in the pathogenesis of various conditions, including malignant tumors, wound repair, chronic inflammation, atherosclerosis and potentially preeclampsia.

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“…MT1-MMP specifically activates the pro-gelatinase, MMP2, on the tumor cell surface in vitro through the formation of a complex with TIMP2 (6). IL8 upregulates MMP2 in tumor cells, which is thought to be responsible for its angiogenic activity (7).…”

Section: Introductionmentioning

confidence: 99%

Underexpression of MMP-2 and its regulators, TIMP2, MT1-MMP and IL-8, is associated with prostate cancer

et al. 2012

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Prostate cancer (PCa) is a common disease with a multifactorial and complex etiology. It is the most common malignancy in the male and the second leading cause of death in many countries, including Brazil. Estimates for 2011 indicate that 903,500 new cases and 258,400 deaths relatVol. 38 (2): 167-174; March -April, 2012 Objective: Extracellular matrix homeostasis is strictly maintained by a coordinated balance between the expression of metalloproteinases (MMPs) and their regulators. The purpose of this study was to investigate whether MMP-2 and its specifi c regulators, TIMP-2, MT1-MMP and IL-8, are expressed in a reproducible, specifi c pattern and if the profi les are related to prognosis and clinical outcome of prostate cancer (PCa). Materials and Methods: MMP-2, TIMP-2, MT1-MMP and IL-8 expression levels were analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) in freshly frozen malignant and benign tissue specimens collected from 79 patients with clinically localized PCa who underwent radical prostatectomies. The control group consisted of 11 patients with benign prostate hyperplasia (BPH). The expression profi le of the MMP-2 and its regulators were compared using Gleason scores, pathological stage, pre-operative PSA levels and the fi nal outcome of the PCa. Results: The analysis of 79 specimens of PCa revealed that MMP-2, TIMP-2, MT1-MMP and IL-8 were underexpressed at 60.0%, 72.2%, 62.0% and 65.8%, respectively, in malignant prostatic tissue in relation to BPH samples. Considering the prognostic parameters, we demonstrated that high Gleason score tumors (≥ 7) overexpressed MMP-2 (p = 0.048) and TIMP-2 (p = 0.021), compared to low Gleason score tumors (< 7). Conclusion: We have demonstrated that MMP-2 and its regulators are underexpressed in PCa. Alternatively, overexpression of MMP-2 and TIMP-2 was related to higher Gleason score tumors. We postulate that alterations in metalloproteinase expression may be important in the control of tissue homeostasis related to prostate carcinogenesis and tumor behavior. Underexpression of MMP-2 and its

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Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins α5 and β1

Cited by 198 publications

References 43 publications

Partial least squares-based gene expression analysis in preeclampsia

Partial least squares-based gene expression analysis in preeclampsia

Association between preeclampsia and the CXC chemokine family (Review)

Underexpression of MMP-2 and its regulators, TIMP2, MT1-MMP and IL-8, is associated with prostate cancer

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