2012
DOI: 10.1016/j.taap.2011.10.002
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Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells

Abstract: The association between chronic human exposure to arsenicals and bladder cancer development is well recognized; however, the underlying molecular mechanisms have not been fully determined. We propose that inflammatory responses can play a pathogenic role in arsenic-related bladder carcinogenesis. In previous studies, it was demonstrated that chronic exposure to 50 nM monomethylarsenous acid [MMA(III)] leads to malignant transformation of an immortalized model of urothelial cells (UROtsa), with only 3 mo of exp… Show more

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Cited by 36 publications
(25 citation statements)
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“…IL-8 serum levels were also associated with the progression of fibrosis [39]. Therefore, IL-8 overexpression might be related to tissue damage [40, 41]. In the current study, a high expression of IL-8 was observed in association with CCl4, and the administration of ginseng extract decreased IL-8 levels to normal values indicating the anti-inflammatory effects of ginseng extract.…”
Section: Discussionsupporting
confidence: 53%
“…IL-8 serum levels were also associated with the progression of fibrosis [39]. Therefore, IL-8 overexpression might be related to tissue damage [40, 41]. In the current study, a high expression of IL-8 was observed in association with CCl4, and the administration of ginseng extract decreased IL-8 levels to normal values indicating the anti-inflammatory effects of ginseng extract.…”
Section: Discussionsupporting
confidence: 53%
“…The role of pro-inflammatory cytokines in arsenic carcinogenesis has become more evident recently. Increased secretion of IL8 and IL6 has been shown to positively correlate with arsenic-induced malignant transformation of urothelial (33) as well as bronchial epithelial cells (18). This study aimed to investigate a possible interaction between autophagy and chronic inflammation and how the interaction relates to arsenic carcinogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, human skin keratinocyte (HaCaT) cells have been malignantly transformed following chronic low-level arsenic exposure (Pi et al, 2008) and have aided in the study of the mechanisms of co-carcinogenic effects of arsenic and ultraviolet irradiation (Sun et al, 2011). Along similar lines, other groups have established and used target cell line relevant models of arsenical carcinogenesis such as transformed human urinary bladder cells (Eblin et al, 2007; Wnek et al, 2010; Escudero-Lourdes et al, 2012; Garrett et al, 2014) or other cell lines including bronchial epithelial cell lines (Stuecke et al, 2012; Xu, et al, 2013) to help better define carcinogenic mechanisms. These have all been a great aid in advancing our knowledge of the remarkable diversity of the toxic and carcinogenic actions of this metalloid.…”
Section: Introductionmentioning
confidence: 99%