Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences

Cotton, James A.; Platnich, Jaye M.; Muruve, Daniel A.; Jijon, Humberto; Buret, André G.; Beck, Paul L.

doi:10.2147/ijicmr.s63682

Cited by 28 publications

(15 citation statements)

References 302 publications

(302 reference statements)

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“…For instance, TGFB1 expression has been related to immunological tolerance towards microbial compounds, including short-chain fatty acids, lactic acid, surface proteins of lactobacilli, peptidoglycan-derived neuropeptides, and histamine (Kashiwagi et al, 2015;Bauché and Marie, 2017;Ihara et al, 2017). Accordingly, decreasing jejunal IL8 and IL10 expression might be associated with the DON-related decreased TLR2 expression and thus with changes in the microbiota composition (Cotton et al, 2016;Kaji et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens1

Lucke

Böhm

Zebeli

et al. 2018

Journal of Animal Science

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Dietary deoxynivalenol (DON) impairs the intestinal immune system and digestive functions of broiler chickens. However, little is known whether increasing doses of DON similarly affect the intestinal functions in different segments of the small intestine in chickens and whether a second oral challenge may potentiate those effects. The present objective was to investigate the effect of increasing dietary DON concentrations on the relative expression of genes for tight junction proteins, mucins, toll-like receptors (TLR), and cytokines in duodenum and jejunum, jejunal mucosal permeability, as well as on α-1acid glycoprotein and IgA in serum with or without an additional oral lipopolysaccharide (LPS) challenge. Eighty 1-d-old chickens were fed diets with increasing DON concentrations (0, 2.5, 5, and 10 mg DON/kg diet) for 5 wk. One day before sampling, half of the chickens received an oral challenge with 1-mg Escherichia coli O55:B5 LPS/ kg BW. Ussing chambers were used to measure the jejunal permeability in birds receiving 10-mg DON/kg feed with or without LPS challenge and 0-mg DON/kg feed without LPS. Increasing DON concentrations of up to 5-mg DON/kg increased (P < 0.05) the duodenal expression of TLR2, IL6, and Claudin 1 (CLDN1) by up to 84%, 88%, and 48%, respectively, compared with the noncontaminated diet. Likewise, jejunal CLDN1 expression increased up to 23% in the chickens fed DON concentrations of up to 5-mg DON/kg diet (P < 0.05). Moreover, increasing DON concentrations linearly and quadratically decreased (P < 0.05) the jejunal expression of TLR2 and transforming growth factor-β 1, respectively. The additional LPS challenge increased (P < 0.040) duodenal occludin expression by 10% as well as the jejunal tissue conductance in chickens of the 10 DON group (P = 0.050). In conclusion, dietary DON differently affected the duodenal and jejunal expression of genes for tight-junction proteins and proinflammatory signaling pathways. The additional LPS challenge did not potentiate the DON effect but it seemed to induce a certain up-regulation of the proinflammatory response in the duodenum and enhanced the mucosal permeability in the jejunum.

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Section: Discussionmentioning

confidence: 99%

Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens1

Lucke

Böhm

Zebeli

et al. 2018

Journal of Animal Science

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“…However, ERK3 is critically required for basal as well as LPSinduced IL-8 levels in both primary and tumour cells. IL-8 was first discovered as a leukocyte chemotactic factor and since then emerged as a double-edged sword of inflammation (Beck et al, 2016;Hammond et al, 1995;Long et al, 2016;Sallusto and Baggiolini, 2008;Singer and Sansonetti, 2004). Further, IL-8 has emerged as a crucial factor in mediating tumour angiogenesis, tumour cell survival and metastasis (David et al, 2016;Feng et al, 2018;Itoh et al, 2005;Li et al, 2003;Waugh and Wilson, 2008;Xu and Fidler, 2000).…”

Section: Discussionmentioning

confidence: 99%

ERK3/MAPK6 controls IL-8 production and chemotaxis

Bogucka

Pompaiah

Marini

et al. 2020

eLife

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ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life remains unclear. By employing gastrointestinal 3D organoids, we detect that ERK3 protein levels steadily decrease during epithelial differentiation. ERK3 is not required for 3D growth of human gastric epithelium. However, ERK3 is stabilized and activated in tumorigenic cells, but deteriorates over time in primary cells in response to lipopolysaccharide (LPS). ERK3 is necessary for production of several cellular factors including interleukin-8 (IL-8), in both, normal and tumorigenic cells. Particularly, ERK3 is critical for AP-1 signaling through its interaction and regulation of c-Jun protein. The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophils and monocytes both in vitro and in vivo. Further, knockdown of ERK3 reduces metastatic potential of invasive breast cancer cells. We unveil an ERK3-mediated regulation of IL-8 and epithelial secretome for chemotaxis.

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“…IL-1 can promote apoptosis, and it is proinflammatory and chemotactic to neutrophils. GM-CSF is a hematopoietic grow factor that recruits various immune cells to host defense [76,86]. Moreover, in the infection course, varies cytokines are also produced by innate and adaptive cell that can also be infected or activated.…”

Section: Cytokines Produced In Viral Infectionsmentioning

confidence: 99%

“…Also, IL-1 is chemotactic factor that induces the passage of neutrophils to the site of infection. This chemotactic function is redundant with the action of IL-8, also known as chemokine CXCL8 [86] also produced by the infected cell. There are cytokines that antagonize these functions of IL-1 such as IL-10, IL-4, and IL-13 recognized for their anti-inflammatory actions [100].…”

Section: Cytokines' Role In Viral Infectionmentioning

confidence: 99%

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Muñoz‐Carrillo¹,

Contreras-Cordero²,

Gutiérrez-Coronado³

et al. 2019

Immune Response Activation and Immunomodulation

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Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response that recognizes pathogenassociated molecular patterns (PAMPs) and an antigen-specific adaptive immune response. In both responses, there are several activated cells of the immune system, which play a key role in establishing the environment of cytokines, thus directing their differentiation either suppressing or promoting the immune response. This immune response is crucial against pathogen infections. In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.

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Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences

Cited by 28 publications

References 302 publications

Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens1

Dietary deoxynivalenol and oral lipopolysaccharide challenge differently affect intestinal innate immune response and barrier function in broiler chickens1

ERK3/MAPK6 controls IL-8 production and chemotaxis

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

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