2008
DOI: 10.1111/j.1582-4934.2008.00429.x
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Interleukin 8 is differently expressed and modulated by PAR‐1 activation in early and late endothelial progenitor cells

Abstract: The proinflammatory chemokine interleukin 8 exerts potent angiogenic effects on endothelial cells by interacting with its receptors CXCR1 and CXCR2. As thrombin is also a potent inflammatory factor, and as endothelial progenitor cells (EPC) express functional PAR-1 thrombin receptor, we examined whether PAR-1 stimulation interferes with the IL-8 pathway in EPC. EPC were obtained from adult blood (AB) and cord blood (CB). The effect of PAR-1 stimulation by the peptide SFLLRN on IL-8, CXCR1 and CXCR2 expression … Show more

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Cited by 29 publications
(21 citation statements)
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“…CFU-Hill colonies were counted after another 3 days, as recommended by the manufacturer. As previously described [7, 13, 24], these cells did not replicate in vitro and gradually disappeared 20 days after plating (Fig. 1b).…”
Section: Methodssupporting
confidence: 78%
“…CFU-Hill colonies were counted after another 3 days, as recommended by the manufacturer. As previously described [7, 13, 24], these cells did not replicate in vitro and gradually disappeared 20 days after plating (Fig. 1b).…”
Section: Methodssupporting
confidence: 78%
“…These cells could be considered as inflammatory cells because they are mobilized in this context. 24 One possible explanation for the lack of mobilization could be inadequate LRP5/LRP6 levels and ␤-catenin pathway activity in inflammatory cells, as observed in CACs.…”
Section: Discussionmentioning
confidence: 99%
“…These cells could be considered as inflammatory cells because they are mobilized in this context. 24 One possible explanation for the lack of mobilization could be inadequate LRP5/LRP6 levels and ␤-catenin pathway activity in inflammatory cells, as observed in CACs.Wnt signaling modulates the stem cell niche and directly modulates stem cell proliferation, expansion, and differentiation. Moreover, Wnt was recently shown to induce embryonic stem cell commitment to the endothelial lineage.…”
mentioning
confidence: 99%
“…These cytokines are produced from the ischemic tissues and from early EPCs. The proinflammatory chemokine IL-8 exerts potent angiogenic effects on endothelial cells, affects significantly endothelial progenitor cells [30], and is known to contribute to their mobilization [31]. We found that IL-8 concentration increased, though not significantly, in blood taken at 12 h after ischemia.…”
Section: Discussionmentioning
confidence: 81%