Interleukin–8 Serum Levels at Fever Onset in Patients with Neutropenia Predict Early Medical Complications

Engel, Andreas K.; Knoll, S.; Kern, Peter; Kern, Winfried V.

doi:10.1007/s15010-005-5068-2

Cited by 20 publications

(17 citation statements)

References 16 publications

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“…High serum IL-8 concentration (1,000 pg ml -1 ) during fever is predictive of subsequent health complications such as sepsis, respiratory insufficiency and death (Engel et al 2005). In our study, serum IL-8 concentration was only in the range of 15-30 pg ml -1 after exercise in 32°C.…”

Section: Discussioncontrasting

confidence: 45%

Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise

et al. 2007

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We investigated the influence of rectal temperature on the immune system during and after exercise. Ten well-trained male cyclists completed exercise trials (90 min cycling at 60% VO(2max) + 16.1 - km time trial) on three separate occasions: once in 18 degrees C and twice in 32 degrees C. Twenty minutes after the trials in 32 degrees C, the cyclists sat for approximately 20 min in cold water (14 degrees C) on one occasion, whereas on another occasion they sat at room temperature. Rectal temperature increased significantly during cycling in both conditions, and was significantly higher after cycling in 32 degrees C than in 18 degrees C (P < 0.05). Leukocyte counts increased significantly during cycling but did not differ between the conditions. The concentrations of serum interleukin (IL)-6, IL-8 and IL-10, plasma catecholamines, granulocyte-colony stimulating factor, myeloperoxidase and calprotectin increased significantly following cycling in both conditions. The concentrations of serum IL-8 (25%), IL-10 (120%), IL-1 receptor antagonist (70%), tumour necrosis factor-alpha (17%), plasma myeloperoxidase (26%) and norepinephrine (130%) were significantly higher after cycling in 32 degrees C than in 18 degrees C. During recovery from exercise in 32 degrees C, rectal temperature was significantly lower in response to sitting in cold water than at room temperature. However, immune changes during 90 min of recovery did not differ significantly between sitting in cold water and at room temperature. The greater rise in rectal temperature during exercise in 32 degrees C increased the concentrations of serum IL-8, IL-10, IL-1ra, TNF-alpha and plasma myeloperoxidase, whereas the greater decline in rectal temperature during cold water immersion after exercise did not affect immune responses.

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Section: Discussioncontrasting

confidence: 45%

Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise

et al. 2007

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“…However, IL-8 correlated positively with circulating CRP and IL-6 in patients with sepsis syndrome [31,32]. The lowest median value for serum IL-8 was found in patients with unexplained fever, high IL-8 levels were correlated with gram-negative bacteremia, based on the above findings it appears that serum IL-8 measurement may be valuable to predict early complicated courses of bacteremia infection in the neutropenic host [11]. In comparison to CRP, the IL-8 level seems to be more worthwhile for discriminating infectious from non-infectious causes in neutropenic febrile patients, especially at the start of febrile episode [33].…”

Section: Discussionmentioning

confidence: 73%

“…This makes IL-6 an interesting molecule to evaluate in the early phase of infection and sepsis [9,10]. In neutropenic patients, enhanced IL-8 production has been demonstrated in predicting bacteremia [11]. Recognition of bacteria by complement components is likely to induce the activation complement pathways leading to the formation of a C3 convertase and the generation of complement activation products triggering diverse biological activities, such as microbial opsonization, phagocyte recruitment and inflammation, resulting in the elimination of pathogenic microorganisms [12,13].…”

Section: Introductionmentioning

confidence: 99%

Serum IL-6, IL-8 and CRP as Markers for Prediction of Bacteremia by Gram Negative Rods in Febrile Cancer Patients and in Irradiated Rats

Farrag¹,

Aboulwafa²,

Aboshanab³

et al. 2017

J Med Microb Diagn

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“…A large number of publications have also addressed the usefulness of inflammatory molecules to predict the outcome of febrile neutropenia episodes 23-25. However, very few studies have tested the ability of circulating inflammatory molecules to predict (or anticipate) the occurrence of fever in this population 11,26-29.…”

Section: Discussionmentioning

confidence: 99%

Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia

Ribeiro

Nobre

Neuenschwander

et al. 2013

Braz J Med Biol Res

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Febrile neutropenia remains a frequent complication in onco-hematological patients, and changes in the circulating level of inflammatory molecules (IM) may precede the occurrence of fever. The present observational prospective study was carried out to evaluate the behavior of plasma tumor necrosis factor alpha (TNF-α), soluble TNF-α I and II receptors (sTNFRI and sTNFRII), monocyte chemoattractant protein-1 [MCP-1 or chemokine (c-c motif) ligand 2 (CCL2)], macrophage inflammatory protein-1α (MIP-1α or CCL3), eotaxin (CCL11), interleukin-8 (IL-8 or CXCL8), and interferon-inducible protein-10 (IP-10 or CXCL10) in 32 episodes of neutropenia in 26 onco-hematological patients. IM were tested on enrollment and 24-48 h before the onset of fever and within 24 h of the first occurrence of fever. Eight of 32 episodes of neutropenia did not present fever (control group) and the patients underwent IM tests on three different occasions. sTNFRI levels, measured a median of 11 h (1-15) before the onset of fever, were significantly higher in patients presenting fever during follow-up compared to controls (P = 0.02). Similar results were observed for sTNFRI and CCL2 levels (P = 0.04 for both) in non-transplanted patients. A cut-off of 1514 pg/mL for sTNFRI was able to discriminate between neutropenic patients with or without fever during follow-up, with 65% sensitivity, 87% specificity, and 93% positive predictive value. Measurement of the levels of plasma sTNFRI can be used to predict the occurrence of fever in neutropenic patients.

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Interleukin–8 Serum Levels at Fever Onset in Patients with Neutropenia Predict Early Medical Complications

Abstract: Interleukin-8 levels at fever onset may be used for the prediction of early medical complications associated with bacteremia and can help identify patients who might benefit from intensive care admission.

Cited by 20 publications

References 16 publications

Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise

Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise

Serum IL-6, IL-8 and CRP as Markers for Prediction of Bacteremia by Gram Negative Rods in Febrile Cancer Patients and in Irradiated Rats

Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia

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