Interleukin (Il-)15 Has Less Activity Than Il-2 to Promote Type 2 Cytokine Predominance in Tumour-Associated Mononuclear Cells From Lung Cancer Patients

Takeuchi, Eiji; Yanagawa, Hiroaki; Suzuki, Yoshihiro; Shinkawa, Kunihiro; Bando, Hiroyasu; Sone, Saburo

doi:10.1006/cyto.2000.0808

Cited by 6 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Structurally similar to IL-2, IL-15 facilitates CD8+ memory T-lymphocyte survival and stimulates proliferation of natural killer cells, dependent on IL-15RA, in the tumor environment (42, 43). Adjuvant IL-15 therapy has been shown to result in tumor regression in a murine lung tumor model (44), underscoring the importance of examining polymorphisms in the IL15 gene.…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non–Small Cell Lung Cancer among Women

Dyke¹,

Coté

Wenzlaff³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Studies on the relationships between inflammatory pathway genes and lung cancer risk have not included African-Americans and have only included a handful of genes. In a population-based case-control study on 198 African-American and 744 Caucasian women, we examined the association between 70 cytokine and cytokine receptor single-nucleotide polymorphisms (SNPs) and risk of non–small cell lung cancer (NSCLC). Unconditional logistic regression was used to estimate odds ratios and 95% confidence intervals in a dominant model adjusting for major risk factors for lung cancer. Separate analyses were conducted by race and by smoking history and history of chronic obstructive pulmonary disease among Caucasians. Random forest analysis was conducted by race. On logistic regression analysis, IL6 (interleukin 6), IL7R, IL15, TNF (tumor necrosis factor), and IL10 SNP were associated with risk of non–small cell lung cancer among African-Americans; IL7R and IL10 SNPs were also associated with risk of lung cancer among Caucasians. Although random forest analysis showed IL7R and IL10 SNPs as being associated with risk for lung cancer among African-Americans, it also identified TNFRSF10A SNP as an important predictor. On random forest analysis, an IL1A SNP was identified as an important predictor of lung cancer among Caucasian women. Inflammatory SNPs differentially predicted risk for NSCLC according to race, as well as based on smoking history and history of chronic obstructive pulmonary disease among Caucasian women. Pathway analysis results are presented. Inflammatory pathway genotypes may serve to define a high risk group; further exploration of these genes in minority populations is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non–Small Cell Lung Cancer among Women

Dyke¹,

Coté

Wenzlaff³

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…IL‐15 appears to enhance both Th1 responses by increasing IFN‐γ production from NK and T cells [13,16,23], and Th2 responses augmenting IL‐5 production [15,23]. However, IL‐15 appears to contribute to the deviation of type 1/type 2 cytokine balance to type 1 predominance [24]. Recently, the ability of IL‐15 to augment the local T‐cell response to Mycobacterium leprae [23] and to enhance immune functions during HIV infection, restoring IL‐12 production [25], has been described.…”

Section: Introductionmentioning

confidence: 99%

IL-15 in human visceral leishmaniasis caused byLeishmania infantum

Milano

Bella

D’Agostino

et al. 2002

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARY Interleukin (IL)‐15 is a recently discovered cytokine with the ability to stimulate the proliferation activity of Th1 and/or Th2 lymphocytes. Here, we investigated the involvement of IL‐15 in the immune response to Leishmania infantum infection by studying patients with visceral leishmaniasis (VL). We found that IL‐15 is produced by leishmanial antigen (LAg)‐stimulated peripheral blood mononuclear cells (PBMC) from active VL patients at a significantly higher level than those produced by cells from healed VL subjects or healthy controls. A significant increase in IL‐15 serum blood levels was also observed in acute VL patients compared with healed ones. Furthermore, recombinant IL‐15 had an appreciable effect in vitro in reducing IL‐4 and increasing the production of IL‐12 in response to LAg, but it was ineffective in altering the production of interferon‐γ (IFN‐γ). The production of endogenous IL‐15 in acute VL patients appeared to be insufficient to activate both IFN‐γ and IL‐12, as attested by the absence of modification of these two cytokines by neutralization experiments in the presence of anti‐IL‐15 monoclonal antibodies (MoAB). On the contrary, the neutralization of IL‐15 increased IL‐4 production. Together, these results indicate that endogenous IL‐15 plays a role in the suppression of Th2‐type cytokines, even though it does not enhance the production of Th1 cytokines in acute VL patients. Since IL‐15, in the presence of anti‐IL‐4 MoAb, caused a further increase in IL‐12 production and led to a significant production of IFN‐γ, one of its indirect effects on Th1 cell activation could be due to the latter’s effect on Th2 cytokines such as IL‐4. Therefore, our observations indicate that there is a potential for IL‐15 to augment the T‐cell response to human intracellular pathogens.

show abstract

Low-dose IL-2 induces cytokine cascade, eosinophilia, and a transient Th2 shift in melanoma patients

Cragun

Yamshchikov

Bissonette

et al. 2005

Cancer Immunol Immunother

View full text Add to dashboard Cite

show abstract

Interleukin (Il-)15 Has Less Activity Than Il-2 to Promote Type 2 Cytokine Predominance in Tumour-Associated Mononuclear Cells From Lung Cancer Patients

Cited by 6 publications

References 14 publications

Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non–Small Cell Lung Cancer among Women

Cytokine and Cytokine Receptor Single-Nucleotide Polymorphisms Predict Risk for Non–Small Cell Lung Cancer among Women

IL-15 in human visceral leishmaniasis caused byLeishmania infantum

Low-dose IL-2 induces cytokine cascade, eosinophilia, and a transient Th2 shift in melanoma patients

Contact Info

Product

Resources

About