Interleukin (IL)‐1β, IL‐1 receptor antagonist, IL‐6, IL‐8, IL‐10, and tumor necrosis factor α gene polymorphisms in patients with febrile seizures

Abstract

Inflammation and genetics may play a role in the pathogenesis of febrile seizures (FSs). We aimed to test whether interleukin-1beta (IL-1beta), IL-1 receptor antagonist (IL-1 Ra), IL-6 promoter, IL-8, IL-10, or tumor necrosis factor (TNF) gene polymorphisms could be used as markers of susceptibility to FSs. An association study was performed among a cohort of 104 patients with FSs and 143 normal control subjects. There was no significant difference between patients and controls in the distribution of allele frequencies of the IL-1beta promoter, IL-1beta exon 5, IL-6 promoter, IL-8, IL-10, or TNF-alpha gene polymorphisms. In contrast, the IL-1 Ra-I homozygote was more frequent in patients with FSs than in healthy controls (93.2% vs. 83.92%, chi(2)=4.51, P=0.034). In addition, individuals homozygous for the IL-1 Ra-I genotype were more than twice as likely to develop FSs than individuals heterozygous for the IL-1 Ra-I/II genotype (OR, 2.63, 95% CI: 1.08-6.39; chi(2)=4.55, P=0.033). We conclude that the IL-1 Ra gene might be one of the useful markers for predicting susceptibility to FSs.

Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

“…Emsley et al found no significant association of TNF-α SNPs, but significant result was for missense SNP rs208294 in P2X7R (purinergic receptor P2X7) [41]. Also, Chou et al demonstrated that IL-1 receptor antagonist allele 1 homozygote was more frequent in patients with FS than in healthy controls, but no significant difference was evident in the distribution of allele frequencies of the IL-1B promoter, IL-1B exon 5, IL-6 promoter, IL-8, IL-10, or the TNF-α gene polymorphism [42].…”

Genomic analysis of the interleukin-1β-511 and interleukin-6-174 gene polymorphisms in Turkish patients with epilepsy

“…We found that the GG genotype was observed at a higher frequency in patients with a family history of seizures, indicating that it could be a risk factor for epilepsy. Reasons for these differences may include geography, ethnicity, and genomic heterogeneity (Tilgen et al, 2002;Chou et al, 2010;Wu et al, 2012). In this study, the GG genotype was the most frequently observed genotype in patients with head trauma and difficult birth, and the G allele frequency was the most common allele.…”

“…The results of Kanemoto et al (2003) agree with our results in many aspects. In contrast, no association between epilepsy and IL-1β polymorphisms was noted by Tiwari et al (2012) in India, Chou et al (2010) in Taiwan, Haspolat et al (2005) in Turkey, Matsuo et al (2006) in Japan, and Capurso et al (2010) in the USA. In addition, Tilgen et al (2002) and Tsai et al (2002) found that the C allele was most frequently observed in febrile seizure patients in German and Taiwanese populations, respectively.…”

Association Between IL1B and SCN1A Polymorphism and Febrile Seizures in Children in Siberia

“…(5) In this regard, a functional polymorphism of cytokine genes is of great interest, since these proteins contribute most to the regulation of immunity, in epilepsy as well. (6)(7)(8) The most frequent causes of differences in gene structure are point mutations, tandem repeats of parts of the gene, and deletions of nucleotides or small gene fragments. The mutant fragments of one or several genes, located very close to each other, can be inherited together (coupling) as the result of selective advantages or, more typically, because of the irregularities of meiotic recombination in this chromosomal region.…”

“…The mutant fragments of one or several genes, located very close to each other, can be inherited together (coupling) as the result of selective advantages or, more typically, because of the irregularities of meiotic recombination in this chromosomal region. (5)(6)(7) Multiple animal studies have shown that the components of the immune response can play some role in FS pathogenesis.…”